Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1993-4-8
pubmed:abstractText
Twenty-three stabilized chronic uremic patients with no active or recent infection were treated for 10 days with either cefodizime (5 x 2 g intravenously, n = 10) or cotrimoxazole (960 mg orally b.i.d., n = 8) in order to evaluate the effects on the depressed polymorphonuclear metabolic response to phagocytic challenge; a separate group of 5 patients received placebo. Ex vivo evaluation in whole blood of energy delivery to the phagocytosis-associated respiratory burst activity in response to latex and zymosan challenge was determined by measuring hexose-monophosphate shunt NAD(P)H-oxidase-related glycolytic activity. Cefodizime induced a statistically significant increase in the baseline-depressed glycolytic response for both latex and zymosan challenge, in contrast to cotrimoxazole and placebo. Depressed phagocytosis-related metabolic function in hemodialyzed patients was stimulated by cefodizime in recommended therapeutic doses but not by cotrimoxazole, the effect persisting for at least 2 weeks after the end of treatment.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0028-2766
pubmed:author
pubmed:issnType
Print
pubmed:volume
63
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
65-72
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:8446254-Adult, pubmed-meshheading:8446254-Aged, pubmed-meshheading:8446254-Cefotaxime, pubmed-meshheading:8446254-Chronic Disease, pubmed-meshheading:8446254-Dose-Response Relationship, Drug, pubmed-meshheading:8446254-Energy Metabolism, pubmed-meshheading:8446254-Female, pubmed-meshheading:8446254-Glycolysis, pubmed-meshheading:8446254-Humans, pubmed-meshheading:8446254-Injections, Intravenous, pubmed-meshheading:8446254-Latex, pubmed-meshheading:8446254-Male, pubmed-meshheading:8446254-Middle Aged, pubmed-meshheading:8446254-NADH, NADPH Oxidoreductases, pubmed-meshheading:8446254-NADPH Oxidase, pubmed-meshheading:8446254-Neutrophils, pubmed-meshheading:8446254-Phagocytes, pubmed-meshheading:8446254-Phagocytosis, pubmed-meshheading:8446254-Renal Dialysis, pubmed-meshheading:8446254-Respiratory Burst, pubmed-meshheading:8446254-Time Factors, pubmed-meshheading:8446254-Trimethoprim-Sulfamethoxazole Combination, pubmed-meshheading:8446254-Uremia, pubmed-meshheading:8446254-Zymosan
pubmed:year
1993
pubmed:articleTitle
Antibiotics and energy delivery to the phagocytosis-associated respiratory burst in chronic hemodialysis patients: a comparison of cefodizime and cotrimoxazole.
pubmed:affiliation
Nephrology Department, University Hospital, Ghent, Belgium.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Controlled Clinical Trial