Linked Life Data

8445210

Source:http://linkedlifedata.com/resource/pubmed/id/8445210

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1993-4-5
pubmed:abstractText
It has been postulated that one of the mechanisms of hypotension associated with cirrhosis is an attenuated responsiveness to catecholamines despite the increased activity of the sympathetic nervous system and the elevated plasma concentrations of the sympathetic neurotransmitter, norepinephrine. This abnormality was studied in a dog model of portal hypertension and cirrhosis. Twelve weeks after bile duct ligation (n = 16), intrasplenic pressure rose significantly from 6.3 +/- 0.4 to 14.6 +/- 1.6 mmHg (p < 0.05), mean arterial pressure had fallen from 106 +/- 4 to 83 +/- 8 mmHg (p < 0.01), cardiac output had risen from 3.1 +/- 0.2 to 3.8 +/- 0.8 l/min (p < 0.05) and plasma norepinephrine concentrations rose from 0.22 +/- 0.12 to 1.17 +/- 0.52 nmol/l (p < 0.05). In 7 sham-operated dogs, the changes in these 4 variables over the same period were non-significant. In vivo pressor responsiveness was tested by studying the effects of intravenous and intra-arterial infusions of norepinephrine and the non-selective beta-adrenoceptor agonist, isoproterenol. In vitro responsiveness was tested by measuring the effects of isoproterenol on the isometric twitch of isolated ventricular strips and the effects of norepinephrine on femoral, mesenteric and renal arterial rings. There was no significant change in the in vivo responses of chronic bile-duct-ligated dogs at 12 weeks compared to the preoperative assessment, or to sham-operated dogs at 12 weeks. Furthermore, there was no significant difference between the in vitro responses of ventricular strips to isoproterenol or arterial rings to norepinephrine prepared from chronic bile-duct-ligated and sham-operated dogs.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0168-8278
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
116-23
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:8445210-Aldosterone, pubmed-meshheading:8445210-Animals, pubmed-meshheading:8445210-Arteries, pubmed-meshheading:8445210-Atrial Natriuretic Factor, pubmed-meshheading:8445210-Bile Ducts, pubmed-meshheading:8445210-Bilirubin, pubmed-meshheading:8445210-Blood Pressure, pubmed-meshheading:8445210-Dogs, pubmed-meshheading:8445210-Dose-Response Relationship, Drug, pubmed-meshheading:8445210-Hypertension, Portal, pubmed-meshheading:8445210-Hypotension, pubmed-meshheading:8445210-Isoproterenol, pubmed-meshheading:8445210-Liver Cirrhosis, Experimental, pubmed-meshheading:8445210-Liver Function Tests, pubmed-meshheading:8445210-Muscle, Smooth, Vascular, pubmed-meshheading:8445210-Muscle Contraction, pubmed-meshheading:8445210-Norepinephrine, pubmed-meshheading:8445210-Plasma Volume, pubmed-meshheading:8445210-Reference Values, pubmed-meshheading:8445210-Renin, pubmed-meshheading:8445210-Serum Albumin, pubmed-meshheading:8445210-Sodium, pubmed-meshheading:8445210-Sodium, Dietary, pubmed-meshheading:8445210-Time Factors
pubmed:year
1993
pubmed:articleTitle
Hypotension in experimental cirrhosis. Is loss of vascular responsiveness to norepinephrine the cause of hypotension in chronic bile-duct-ligated dogs?
pubmed:affiliation
Department of Pharmacology, Faculty of Medicine, Technion-Israel Institute of Technology Haifa, Israel.
pubmed:publicationType
Journal Article, In Vitro