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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1993-4-6
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| pubmed:abstractText |
In children with the congenital central hypoventilation syndrome (CCHS), some patients require mechanical ventilation during sleep, whereas others need respiratory assistance even when awake. The cause of this disparity is unclear. We hypothesized that differences in peripheral chemoreceptor response (PCR) could provide an explanatory mechanism for this disparity in clinical manifestations. PCR was measured in five children with CCHS and five sex- and age-matched controls by measuring the ventilatory responses induced by 100% O2 breathing, five tidal breaths of 100% N2, and vital capacity breaths of 5% and 15% CO2 in O2 and 5% CO2-95% N2. Tidal breathing of 100% O2 resulted in similar ventilatory responses in CCHS patients and controls with various changes dependent on the method of analysis of response used. Acute hypoxia by N2 tidal breathing resulted in a 39.2 +/- 22% increase in respiratory rate in CCHS patients and a 15.1 +/- 11.1% increase in controls (P < 0.05), with similar increases in minute ventilation (VE) of 124 +/- 69% and 85 +/- 11%, respectively. Vital capacity breaths of each of the CO2-containing gas mixtures induced similar increases in VE in CCHS patients and controls. The changes in VE obtained with 15% CO2-85% O2 and with 5% CO2-95% N2 were significantly greater than those with 5% CO2-95% O2, suggesting a dose-dependent response as well as additive effects of hypercapnic and hypoxic stimuli. We conclude that the PCR, when assessed by acute hypoxia, hyperoxia, or hypercapnia, is present and intact in CCHS children who are able to sustain adequate ventilation during wakefulness.(ABSTRACT TRUNCATED AT 250 WORDS)
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
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| pubmed:issn |
8750-7587
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
74
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
379-87
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:8444717-Adolescent,
pubmed-meshheading:8444717-Anoxia,
pubmed-meshheading:8444717-Carbon Dioxide,
pubmed-meshheading:8444717-Chemoreceptor Cells,
pubmed-meshheading:8444717-Child,
pubmed-meshheading:8444717-Female,
pubmed-meshheading:8444717-Humans,
pubmed-meshheading:8444717-Hypoventilation,
pubmed-meshheading:8444717-Male,
pubmed-meshheading:8444717-Neural Pathways,
pubmed-meshheading:8444717-Oxygen,
pubmed-meshheading:8444717-Peripheral Nerves,
pubmed-meshheading:8444717-Respiration, Artificial,
pubmed-meshheading:8444717-Respiratory Function Tests,
pubmed-meshheading:8444717-Respiratory Mechanics,
pubmed-meshheading:8444717-Syndrome,
pubmed-meshheading:8444717-Vital Capacity,
pubmed-meshheading:8444717-Wakefulness
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Peripheral chemoreceptor function in children with the congenital central hypoventilation syndrome.
|
| pubmed:affiliation |
Division of Neonatology and Pediatric Pulmonology, Childrens Hospital Los Angeles, California.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|