Linked Life Data

8444378

Source:http://linkedlifedata.com/resource/pubmed/id/8444378

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1993-4-7
pubmed:abstractText
We developed an automatic analyzing system using a personal computer to evaluate gastric motility objectively. Gastric motility was divided into three elements: motility index, amplitude and frequency. These elements analyzed with both computer and manual methods closely correlated with each other (R2 = 0.943, 0.985 and 0.986, respectively). The effect of Y-25130 on gastric motility was investigated in anesthetized rats with the automatic analyzing system. Intravenous administration of Y-25130 increased both spontaneous and cisplatin-reduced gastric motility. The effect of Y-25130 on spontaneous motility was superior to that of ondansetron and metoclopramide, and the effect on cisplatin-reduced motility was almost the same as that of ondansetron and superior to that of metoclopramide. In vagotomized rats, Y-25130 did not increase the gastric motility not only in spontaneous conditions but also in efferent vagus stimulated conditions. Atropine completely blocked the gastric motility induced by Y-25130. In capsaicin pre-treated rats, Y-25130 had no effect. On the other hand, Y-25130 increased the gastric motility induced by afferent vagus stimulation. These results suggest that Y-25130 increases gastric motility through the vagus nerve and acts on afferent neurons.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0015-5691
pubmed:author
pubmed:issnType
Print
pubmed:volume
101
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
17-26
pubmed:dateRevised
2011-7-27
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
[Effect of Y-25130 on gastric motility in anesthetized rats].
pubmed:affiliation
Research Laboratories, Yoshitomi Pharmaceutical Industries, Ltd., Fukuoka, Japan.
pubmed:publicationType
Journal Article, English Abstract