|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
1993-4-2
|
|
pubmed:abstractText |
The concomitant activation of macrophage-mediated immunosuppressive events might represent one of the most important biologic factors responsible for the decreased efficacy of cancer immunotherapies, including that of interleukin (IL)-2. In previous studies, the authors observed that the increase in the soluble IL-2 receptor (SIL-2R) and neopterin levels was related to the generation of macrophage-mediated immunosuppression and associated with a reduced clinical efficacy during IL-2 cancer immunotherapy. Because both cytokines and neurohormones may influence the macrophage system, the current study was done to evaluate the effects of IL-3 and of the pineal hormone melatonin (MLT) on monocyte response to IL-2 administration.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0008-543X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
71
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
N
|
|
pubmed:pagination |
2076-81
|
|
pubmed:dateRevised |
2010-3-24
|
|
pubmed:meshHeading |
pubmed-meshheading:8443757-Biopterin,
pubmed-meshheading:8443757-Humans,
pubmed-meshheading:8443757-Immunotherapy,
pubmed-meshheading:8443757-Interleukin-2,
pubmed-meshheading:8443757-Interleukin-3,
pubmed-meshheading:8443757-Macrophage Activation,
pubmed-meshheading:8443757-Melatonin,
pubmed-meshheading:8443757-Neopterin,
pubmed-meshheading:8443757-Receptors, Interleukin-2,
pubmed-meshheading:8443757-Tumor Necrosis Factor-alpha
|
|
pubmed:year |
1993
|
|
pubmed:articleTitle |
In vitro modulatory effects of interleukin-3 on macrophage activation induced by interleukin-2.
|
|
pubmed:affiliation |
Division of Radiation Oncology, San Gerardo Hospital, Milan, Italy.
|
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|
