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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1993-4-5
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pubmed:abstractText |
MRL-lpr/lpr mice have hypertrophied lymph nodes comprising CD4-CD8- T cells. In addition, they contain CD4+CD8- T cells co-expressing the CD45RA marker. The correlation between these two subpopulations has been difficult to assess. We analyzed the expression of CD45RA (with the RA3-2C2 antibody) in various thymic and peripheral T cell subsets, using three-color immunofluorescence. We showed that in lpr mice (i) a transient CD4+CD8- thymic subset co-expresses CD45RA during the course of the disease, and (ii) thymic as well as peripheral CD4-CD8- and CD4+CD8- T cells brightly express CD45RA; furthermore (iii) in the lymph nodes, during lymphadenopathy, CD4+CD8-CD45RA+ T cells show a broad range of the CD4 fluorescence intensity, and (iv) the increase in MHC class II expression is restricted to CD45RA-T cells of the thymus and lymph nodes of lpr mice. Taken together, these data suggest that the CD4+CD8-CD45RA+ population might generate the CD4-CD8- tumor cells. In addition, using the bromodeoxyuridine labeling technique, we demonstrate that these cells are not the result of increased proliferation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD3,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD45,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD8,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class II,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell...
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0953-8178
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
89-96
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:8443124-Animals,
pubmed-meshheading:8443124-Antigens, CD3,
pubmed-meshheading:8443124-Antigens, CD4,
pubmed-meshheading:8443124-Antigens, CD45,
pubmed-meshheading:8443124-Antigens, CD8,
pubmed-meshheading:8443124-DNA,
pubmed-meshheading:8443124-Flow Cytometry,
pubmed-meshheading:8443124-Gene Expression,
pubmed-meshheading:8443124-Histocompatibility Antigens Class II,
pubmed-meshheading:8443124-Immunophenotyping,
pubmed-meshheading:8443124-Lymph Nodes,
pubmed-meshheading:8443124-Lymphatic Diseases,
pubmed-meshheading:8443124-Lymphocyte Activation,
pubmed-meshheading:8443124-Mice,
pubmed-meshheading:8443124-Mice, Inbred Strains,
pubmed-meshheading:8443124-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:8443124-T-Lymphocyte Subsets,
pubmed-meshheading:8443124-Thymus Gland,
pubmed-meshheading:8443124-Time Factors,
pubmed-meshheading:8443124-Tumor Cells, Cultured
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pubmed:year |
1993
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pubmed:articleTitle |
A novel CD45RA+CD4+ transient thymic subpopulation in MRL-lpr/lpr mice: its relation to non-proliferating CD4-CD8-CD45RA+ tumor cells.
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pubmed:affiliation |
U345 INSERM, CHU Necker-Enfants Malades, Paris, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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