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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1993-4-1
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pubmed:abstractText |
Polycystic kidney disease (PKD) is characterized by progressive enlargement of the kidneys due to numerous expanding cysts ultimately leading to renal failure. We have identified a gene, Ke 6, located within the H-2K/tw5 region on mouse chromosome 17, which is downregulated in two distinct murine models of heritable PKD. Ke 6 is a member of the short-chain alcohol dehydrogenase family and possess remarkable amino acid sequence conservation with several bacterial proteins with oxidoreductase function. The Ke 6 gene gives rise to two transcripts--a 1-kb Ke 6a mRNA which is abundant in kidney and liver tissue and a 1.4-kb Ke 6b mRNA which is found at a moderate level in spleen tissue. We report here the complete nucleotide sequence of Ke 6a cDNA and the expression of the Ke 6 gene in murine models of PKD. The Ke 6 gene may be intimately involved in the manifestation of these cystic kidney diseases.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8441417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8441417-1338768,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8441417-1339305,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/8441417-7377224
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0270-7306
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
13
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pubmed:geneSymbol |
Ke 6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1847-53
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pubmed:dateRevised |
2010-9-10
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pubmed:meshHeading |
pubmed-meshheading:8441417-Alcohol Dehydrogenase,
pubmed-meshheading:8441417-Amino Acid Sequence,
pubmed-meshheading:8441417-Animals,
pubmed-meshheading:8441417-Bacterial Proteins,
pubmed-meshheading:8441417-Base Sequence,
pubmed-meshheading:8441417-Cell-Free System,
pubmed-meshheading:8441417-Chromosome Mapping,
pubmed-meshheading:8441417-Cloning, Molecular,
pubmed-meshheading:8441417-Cosmids,
pubmed-meshheading:8441417-Disease Models, Animal,
pubmed-meshheading:8441417-Down-Regulation,
pubmed-meshheading:8441417-Histocompatibility Antigens,
pubmed-meshheading:8441417-Major Histocompatibility Complex,
pubmed-meshheading:8441417-Mice,
pubmed-meshheading:8441417-Mice, Mutant Strains,
pubmed-meshheading:8441417-Molecular Sequence Data,
pubmed-meshheading:8441417-Oxidoreductases,
pubmed-meshheading:8441417-Polycystic Kidney Diseases,
pubmed-meshheading:8441417-Protein Biosynthesis,
pubmed-meshheading:8441417-RNA, Messenger,
pubmed-meshheading:8441417-Rats,
pubmed-meshheading:8441417-Rats, Mutant Strains,
pubmed-meshheading:8441417-Sequence Alignment,
pubmed-meshheading:8441417-Tissue Distribution
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pubmed:year |
1993
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pubmed:articleTitle |
Downregulation of Ke 6, a novel gene encoded within the major histocompatibility complex, in murine polycystic kidney disease.
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pubmed:affiliation |
Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
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pubmed:publicationType |
Journal Article,
Comparative Study
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