Linked Life Data

8441393

Source:http://linkedlifedata.com/resource/pubmed/id/8441393

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1993-4-1
pubmed:abstractText
In mammals, hibernation is expressed by only a limited number of species, and the molecular mechanisms underlying hibernation are not well understood. Recently, we have found plasma proteins which disappear from blood specifically during hibernation in a mammalian hibernator, the chipmunk. Here, we report the cDNA cloning of these chipmunk hibernation-related proteins, HP-20, -25, and -27, and analyses of their expression. All three proteins contain a collagen-like domain near the N terminus and are highly homologous to each other. Their mRNAs were detected only in liver in nonhibernating chipmunks, and in hibernating chipmunks, the amounts were reduced to less than 1/10 of those in nonhibernating chipmunks, indicating that HP-20, -25, and -27 mRNA expression is regulated similarly in association with hibernation. Southern blot analyses of the squirrel family with each of chipmunk HP-20, -25, and -27 cDNA revealed that a nonhibernating species (tree squirrel) as well as another hibernating species (ground squirrel) retained the corresponding genes. However, their transcripts were detected only with the hibernating species, and in hibernating ground squirrels, their levels were greatly reduced compared with those in nonhibernating animals, as were the cases with the chipmunk. These observations are the first line of evidence for occurrence of hibernation-associated gene regulation. The results would indicate the commitment of HP-20, -25, and -27 to hibernation and support the idea that genetic controls are involved in mammalian hibernation.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8441393-1730610, http://linkedlifedata.com/resource/pubmed/commentcorrection/8441393-1840520, http://linkedlifedata.com/resource/pubmed/commentcorrection/8441393-1993651, http://linkedlifedata.com/resource/pubmed/commentcorrection/8441393-2011500, http://linkedlifedata.com/resource/pubmed/commentcorrection/8441393-2072906, http://linkedlifedata.com/resource/pubmed/commentcorrection/8441393-2300204, http://linkedlifedata.com/resource/pubmed/commentcorrection/8441393-2661270, http://linkedlifedata.com/resource/pubmed/commentcorrection/8441393-271968, http://linkedlifedata.com/resource/pubmed/commentcorrection/8441393-3009480, http://linkedlifedata.com/resource/pubmed/commentcorrection/8441393-3094014, http://linkedlifedata.com/resource/pubmed/commentcorrection/8441393-3290208, http://linkedlifedata.com/resource/pubmed/commentcorrection/8441393-3299377, http://linkedlifedata.com/resource/pubmed/commentcorrection/8441393-3349522, http://linkedlifedata.com/resource/pubmed/commentcorrection/8441393-3863100, http://linkedlifedata.com/resource/pubmed/commentcorrection/8441393-6298023
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0270-7306
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1516-21
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Hibernation-associated gene regulation of plasma proteins with a collagen-like domain in mammalian hibernators.
pubmed:affiliation
Laboratory of Molecular Biology, School of Hygienic Sciences, Kitasato University, Kanagawa, Japan.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't