| pubmed-article:8441178 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8441178 | lifeskim:mentions | umls-concept:C0999699 | lld:lifeskim |
| pubmed-article:8441178 | lifeskim:mentions | umls-concept:C0596981 | lld:lifeskim |
| pubmed-article:8441178 | lifeskim:mentions | umls-concept:C0018787 | lld:lifeskim |
| pubmed-article:8441178 | lifeskim:mentions | umls-concept:C0036226 | lld:lifeskim |
| pubmed-article:8441178 | lifeskim:mentions | umls-concept:C0076374 | lld:lifeskim |
| pubmed-article:8441178 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:8441178 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:8441178 | lifeskim:mentions | umls-concept:C0205171 | lld:lifeskim |
| pubmed-article:8441178 | lifeskim:mentions | umls-concept:C1550605 | lld:lifeskim |
| pubmed-article:8441178 | lifeskim:mentions | umls-concept:C0456205 | lld:lifeskim |
| pubmed-article:8441178 | lifeskim:mentions | umls-concept:C1140999 | lld:lifeskim |
| pubmed-article:8441178 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8441178 | pubmed:dateCreated | 1993-3-26 | lld:pubmed |
| pubmed-article:8441178 | pubmed:abstractText | Contractures initiated by 1 s superfusion of single myocytes of guinea-pig heart with 10 mM caffeine were used as a relative index of the SR Ca2+ content. Thapsigargin (Tg) in concentration 2 x 10(-7) M completely blocked Ca2+ uptake during electrical stimulation by the SR from which Ca2+ has been previously depleted by caffeine. Tg did not affect the SR Ca2+ content in the resting myocytes and did not block release of the SR Ca2+ during electrically stimulated contractions (ESCs). It is concluded that in guinea-pig myocytes Tg affects SR Ca2+ by selective blocking the SR Ca2+ uptake. The amplitude of steady state ESCs dropped to 68 +/- 5.4% (S.D., n = 20) of that of the pre-Tg control. Time to peak contraction increased from 454 +/- 82.4 ms to 820 +/- 157.4 ms and time of relaxation increased from 368 +/- 90.8 ms to 474 +/- 87 ms after the SR Ca2+ has been depleted by Tg. Rest decay of contractions, post-extrasystolic potentiation and post-rest potentiation were inhibited. | lld:pubmed |
| pubmed-article:8441178 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8441178 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8441178 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8441178 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8441178 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8441178 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8441178 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8441178 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8441178 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:8441178 | pubmed:issn | 0022-2828 | lld:pubmed |
| pubmed-article:8441178 | pubmed:author | pubmed-author:LewartowskiBB | lld:pubmed |
| pubmed-article:8441178 | pubmed:author | pubmed-author:WolskaB MBM | lld:pubmed |
| pubmed-article:8441178 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8441178 | pubmed:volume | 25 | lld:pubmed |
| pubmed-article:8441178 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8441178 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8441178 | pubmed:pagination | 23-9 | lld:pubmed |
| pubmed-article:8441178 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:8441178 | pubmed:meshHeading | pubmed-meshheading:8441178-... | lld:pubmed |
| pubmed-article:8441178 | pubmed:meshHeading | pubmed-meshheading:8441178-... | lld:pubmed |
| pubmed-article:8441178 | pubmed:meshHeading | pubmed-meshheading:8441178-... | lld:pubmed |
| pubmed-article:8441178 | pubmed:meshHeading | pubmed-meshheading:8441178-... | lld:pubmed |
| pubmed-article:8441178 | pubmed:meshHeading | pubmed-meshheading:8441178-... | lld:pubmed |
| pubmed-article:8441178 | pubmed:meshHeading | pubmed-meshheading:8441178-... | lld:pubmed |
| pubmed-article:8441178 | pubmed:meshHeading | pubmed-meshheading:8441178-... | lld:pubmed |
| pubmed-article:8441178 | pubmed:meshHeading | pubmed-meshheading:8441178-... | lld:pubmed |
| pubmed-article:8441178 | pubmed:meshHeading | pubmed-meshheading:8441178-... | lld:pubmed |
| pubmed-article:8441178 | pubmed:meshHeading | pubmed-meshheading:8441178-... | lld:pubmed |
| pubmed-article:8441178 | pubmed:meshHeading | pubmed-meshheading:8441178-... | lld:pubmed |
| pubmed-article:8441178 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8441178 | pubmed:articleTitle | The effect of thapsigargin on sarcoplasmic reticulum Ca2+ content and contractions in single myocytes of guinea-pig heart. | lld:pubmed |
| pubmed-article:8441178 | pubmed:affiliation | Department of Clinical Physiology, Medical Centre of Postgraduate Education, Warsaw, Poland. | lld:pubmed |
| pubmed-article:8441178 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8441178 | pubmed:publicationType | In Vitro | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8441178 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8441178 | lld:pubmed |
