Linked Life Data

8440085

Source:http://linkedlifedata.com/resource/pubmed/id/8440085

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1993-3-31
pubmed:abstractText
The effects in vitro of Cefoxitin, a beta-lactam antibiotic, at a concentration of 50 micrograms/ml (similar to a therapeutic level in plasma) on each step of the phagocytic process, in addition to antibody-dependent cellular cytotoxicity (ADCC) of blood peripheral human neutrophils have been studied. The antibiotic produced a significant stimulation of adherence capacity, chemotaxis, attachment of Candida albicans to neutrophils and phagocytosis of Candida albicans (with serum, decomplemented serum or without serum), ingestion of inert particles (latex beads), microbicidal activity, and digestion capacity of the ingested material [measured by nitroblue tetrazolium (NBT) reduction]. Moreover, cefoxitin (50 micrograms/ml) demonstrated chemoattractant activity for neutrophils. ADCC was also increased by this antimicrobial agent. These results therefore suggest that a therapeutic concentration of cefoxitin may enhance microbicidal and cytotoxic functions of a pivotal human phagocytic cell: the neutrophil.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0147-9571
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
37-50
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
In vitro effect of cefoxitin on phagocytic function and antibody-dependent cellular cytotoxicity in human neutrophils.
pubmed:affiliation
Department of Physiology, Faculty of Science, University of Extremadura, Badajoz, Spain.
pubmed:publicationType
Journal Article, In Vitro