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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1993-4-1
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pubmed:abstractText |
The distribution of phosphatidylcholine between inner and outer monolayers of rat brain synaptic plasma membrane was investigated by means of a phosphatidylcholine specific exchange protein. About 70% of the total membranal phosphatidylcholine was in the outer leaflet, 33% of which was exposed and readily exchanged in intact synaptosomes while the remainder was exchangeable following osmotic shock. Permeabilization of the synaptic plasma membranes by overnight incubation in buffer or by saponin (< 0.08%) exposed an additional 30% of phosphatidylcholine to exchange, presumably from the inner cytoplasmic leaflet. Phosphatidylcholine is therefore asymmetrically distributed in the synaptosomal plasma membrane, as it is in other plasma membranes.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Androgen-Binding Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Buffers,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylcholines,
http://linkedlifedata.com/resource/pubmed/chemical/Phospholipid Transfer Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Prostatein,
http://linkedlifedata.com/resource/pubmed/chemical/Psbpc1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Psbpc2 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Saponins,
http://linkedlifedata.com/resource/pubmed/chemical/Scgb2a2 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Secretoglobins,
http://linkedlifedata.com/resource/pubmed/chemical/Uteroglobin
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0197-0186
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
189-95
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:8439772-Androgen-Binding Protein,
pubmed-meshheading:8439772-Animals,
pubmed-meshheading:8439772-Brain Chemistry,
pubmed-meshheading:8439772-Buffers,
pubmed-meshheading:8439772-Carrier Proteins,
pubmed-meshheading:8439772-Cell Membrane Permeability,
pubmed-meshheading:8439772-Kinetics,
pubmed-meshheading:8439772-Male,
pubmed-meshheading:8439772-Phosphatidylcholines,
pubmed-meshheading:8439772-Phospholipid Transfer Proteins,
pubmed-meshheading:8439772-Prostatein,
pubmed-meshheading:8439772-Rats,
pubmed-meshheading:8439772-Rats, Sprague-Dawley,
pubmed-meshheading:8439772-Saponins,
pubmed-meshheading:8439772-Secretoglobins,
pubmed-meshheading:8439772-Synaptic Membranes,
pubmed-meshheading:8439772-Synaptosomes,
pubmed-meshheading:8439772-Tissue Distribution,
pubmed-meshheading:8439772-Uteroglobin
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pubmed:year |
1993
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pubmed:articleTitle |
The asymmetric distribution of phosphatidylcholine in rat brain synaptic plasma membranes.
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pubmed:affiliation |
Basil and Gerald Felsenstein Medical Research Center, Rogoff-Wellcome Medical Research Institute, Sackler School of Medicine, Tel Aviv University, Beilinson Medical Center, Petah Tikva, Israel.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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