| pubmed-article:8438613 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8438613 | lifeskim:mentions | umls-concept:C0020971 | lld:lifeskim |
| pubmed-article:8438613 | lifeskim:mentions | umls-concept:C0442027 | lld:lifeskim |
| pubmed-article:8438613 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8438613 | pubmed:dateCreated | 1993-3-23 | lld:pubmed |
| pubmed-article:8438613 | pubmed:abstractText | Ovalbumin (OVA) was entrapped in poly(lactide-co-glycolide) microparticles and administered to mice. Following intraperitoneal immunization, the microparticles induced both proliferative T-cell responses and cytotoxic T-cell responses in spleen cells. Following oral immunization, the mean salivary IgA antibody response to microparticles was significantly greater than the response to soluble OVA (p < 0.0001). Serum IgG antibody levels were also significantly greater in the group administered microparticles (p < 0.001). Cholera toxin B subunit was also entrapped in microparticles. Following oral immunization in mice, specific antibody-secreting cells were detected both in the spleens and in the mesenteric lymph nodes. | lld:pubmed |
| pubmed-article:8438613 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8438613 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8438613 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8438613 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8438613 | pubmed:issn | 0264-410X | lld:pubmed |
| pubmed-article:8438613 | pubmed:author | pubmed-author:HolmgrenJJ | lld:pubmed |
| pubmed-article:8438613 | pubmed:author | pubmed-author:ChallacombeS... | lld:pubmed |
| pubmed-article:8438613 | pubmed:author | pubmed-author:RahmanDD | lld:pubmed |
| pubmed-article:8438613 | pubmed:author | pubmed-author:McGeeJ PJP | lld:pubmed |
| pubmed-article:8438613 | pubmed:author | pubmed-author:MillsK HKH | lld:pubmed |
| pubmed-article:8438613 | pubmed:author | pubmed-author:MowatA MAM | lld:pubmed |
| pubmed-article:8438613 | pubmed:author | pubmed-author:O'HaganD TDT | lld:pubmed |
| pubmed-article:8438613 | pubmed:author | pubmed-author:DonachieA MAM | lld:pubmed |
| pubmed-article:8438613 | pubmed:author | pubmed-author:GaisfordWW | lld:pubmed |
| pubmed-article:8438613 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8438613 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:8438613 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8438613 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8438613 | pubmed:pagination | 149-54 | lld:pubmed |
| pubmed-article:8438613 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:8438613 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8438613 | pubmed:articleTitle | Biodegradable microparticles for oral immunization. | lld:pubmed |
| pubmed-article:8438613 | pubmed:affiliation | Department of Pharmaceutical Sciences, University of Nottingham, University Park, UK. | lld:pubmed |
| pubmed-article:8438613 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8438613 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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