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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1993-3-23
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pubmed:abstractText |
Ovalbumin (OVA) was entrapped in poly(lactide-co-glycolide) microparticles and administered to mice. Following intraperitoneal immunization, the microparticles induced both proliferative T-cell responses and cytotoxic T-cell responses in spleen cells. Following oral immunization, the mean salivary IgA antibody response to microparticles was significantly greater than the response to soluble OVA (p < 0.0001). Serum IgG antibody levels were also significantly greater in the group administered microparticles (p < 0.001). Cholera toxin B subunit was also entrapped in microparticles. Following oral immunization in mice, specific antibody-secreting cells were detected both in the spleens and in the mesenteric lymph nodes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0264-410X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
149-54
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8438613-Administration, Oral,
pubmed-meshheading:8438613-Animals,
pubmed-meshheading:8438613-Antibodies, Viral,
pubmed-meshheading:8438613-Biodegradation, Environmental,
pubmed-meshheading:8438613-Cholera Toxin,
pubmed-meshheading:8438613-Delayed-Action Preparations,
pubmed-meshheading:8438613-Drug Compounding,
pubmed-meshheading:8438613-Emulsions,
pubmed-meshheading:8438613-Immunoglobulin A, Secretory,
pubmed-meshheading:8438613-Immunoglobulin G,
pubmed-meshheading:8438613-Injections, Intraperitoneal,
pubmed-meshheading:8438613-Lymph Nodes,
pubmed-meshheading:8438613-Male,
pubmed-meshheading:8438613-Mice,
pubmed-meshheading:8438613-Mice, Inbred BALB C,
pubmed-meshheading:8438613-Microspheres,
pubmed-meshheading:8438613-Ovalbumin,
pubmed-meshheading:8438613-Polyglactin 910,
pubmed-meshheading:8438613-Spleen,
pubmed-meshheading:8438613-T-Lymphocyte Subsets
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pubmed:year |
1993
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pubmed:articleTitle |
Biodegradable microparticles for oral immunization.
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pubmed:affiliation |
Department of Pharmaceutical Sciences, University of Nottingham, University Park, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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