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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1993-3-23
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pubmed:abstractText |
Nuclei of cells infected with Moloney murine leukemia virus (MoMuLV) were examined for the presence of gag proteins. This analysis was performed in conjunction with other studies suggesting a possible role for gag proteins in regulating nuclear events relating to processing and/or transport of viral genomic RNA. We detected Pr65gag and a p30-related protein in a nuclear fraction of infected cells. We also found evidence that a highly conserved amino acid sequence, which is shared by p30 and U1 small nuclear ribonucleoprotein 70-kDa protein, is a component of the nuclear targeting sequence for Pr65gag. Immunoelectron microscopy studies with a monoclonal anti-p12 antibody established that approximately 18% of gag-containing proteins of MoMuLV are located in the nucleus. Such gag-containing proteins from a mutant MoMuLV that lacks N-terminal myristic acid had greater affinity for the nucleus, suggesting that fatty acid acylation of Pr65gag plays a role in overcoming the proposed nuclear transport signal. The possible roles that nuclear gag proteins may play in retroviral replication are discussed.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8437220-1664152,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8437220-1712670,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8437220-1871977,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8437220-1920640,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8437220-2004116,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8437220-2139037,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8437220-2153242,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8437220-2458287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8437220-2959371,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8437220-2982040,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8437220-3001353,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8437220-316537,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8437220-3489936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8437220-388439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8437220-4119788,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8437220-462797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8437220-4798989,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8437220-5432063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8437220-543547,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8437220-6096692,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8437220-6169847,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8437220-6169994,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8437220-6173134,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8437220-6260992,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8437220-6296395,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8437220-6300456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8437220-6302307,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8437220-6305011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8437220-6322433,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8437220-6323748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8437220-6340098,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8437220-70879,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8437220-7273137,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8437220-7423857,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8437220-803875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8437220-94357
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
67
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1350-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8437220-3T3 Cells,
pubmed-meshheading:8437220-Amino Acid Sequence,
pubmed-meshheading:8437220-Animals,
pubmed-meshheading:8437220-Antineoplastic Agents,
pubmed-meshheading:8437220-Biological Transport,
pubmed-meshheading:8437220-Cell Compartmentation,
pubmed-meshheading:8437220-Cell Fractionation,
pubmed-meshheading:8437220-Cell Nucleus,
pubmed-meshheading:8437220-Cytoplasm,
pubmed-meshheading:8437220-Egg Proteins,
pubmed-meshheading:8437220-Gene Products, gag,
pubmed-meshheading:8437220-Mice,
pubmed-meshheading:8437220-Microscopy, Immunoelectron,
pubmed-meshheading:8437220-Molecular Sequence Data,
pubmed-meshheading:8437220-Moloney murine leukemia virus,
pubmed-meshheading:8437220-Protein Sorting Signals,
pubmed-meshheading:8437220-Ribonucleases,
pubmed-meshheading:8437220-Ribonucleoprotein, U1 Small Nuclear
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pubmed:year |
1993
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pubmed:articleTitle |
A subset of Pr65gag is nucleus associated in murine leukemia virus-infected cells.
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pubmed:affiliation |
Department of Molecular Pathology, University of Texas M. D. Anderson Cancer Center, Houston 77030.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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