| pubmed-article:8436253 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8436253 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:8436253 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:8436253 | lifeskim:mentions | umls-concept:C0014792 | lld:lifeskim |
| pubmed-article:8436253 | lifeskim:mentions | umls-concept:C0229960 | lld:lifeskim |
| pubmed-article:8436253 | lifeskim:mentions | umls-concept:C0017725 | lld:lifeskim |
| pubmed-article:8436253 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:8436253 | lifeskim:mentions | umls-concept:C0232105 | lld:lifeskim |
| pubmed-article:8436253 | lifeskim:mentions | umls-concept:C1707797 | lld:lifeskim |
| pubmed-article:8436253 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8436253 | pubmed:dateCreated | 1993-3-25 | lld:pubmed |
| pubmed-article:8436253 | pubmed:abstractText | Insulin resistance in Type 1 (insulin-dependent) diabetes mellitus may be associated with raised erythrocyte sodium-lithium countertransport activity in patients with hypertension, or nephropathy, or both. However, in these circumstances it is difficult to separate the impact of hypertension, hyperlipidaemia and nephropathy on erythrocyte sodium-lithium countertransport from that of insulin resistance. We have therefore examined the relationship between insulin-mediated glucose disposal and erythrocyte sodium-lithium countertransport in 41 normotensive (mean blood pressure 120/74 mmHg), normoalbuminuric (mean albumin excretion 6.2 micrograms/min), normolipidaemic (mean serum cholesterol 4.3 mmol/l and mean serum triglycerides 1.0 mmol/l) Type 1 diabetic patients. Erythrocyte sodium-lithium countertransport was on average 0.31 mmol Li.h-1.l erythrocytes-1 (range 0.07-0.69). Nine patients had values above 0.40 mmol Li.h-1.l erythrocytes-1 (0.51 +/- 0.10 mmol Li.h-1.l erythrocytes-1). The patients with high erythrocyte sodium-lithium countertransport were matched for age, sex, BMI, HbA1 and duration of diabetes, with nine patients with normal erythrocyte sodium-lithium countertransport. Insulin-mediated glucose disposal was evaluated during the last hour of a euglycaemic clamp (insulin 0.015 U.kg-1.h-1; blood glucose clamped at 7.0 mmol/l). The free insulin levels were comparable between the patients with high and normal erythrocyte sodium-lithium countertransport (37.2 +/- 14.7 mU/l and 34.7 +/- 17.2 mU/l respectively). Insulin-mediated glucose disposal was on average 3.1 +/- 1.5 (range 0.8-6.8) mg.kg-1.min-1.(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
| pubmed-article:8436253 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8436253 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8436253 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8436253 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8436253 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8436253 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8436253 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8436253 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8436253 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8436253 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8436253 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8436253 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:8436253 | pubmed:issn | 0012-186X | lld:pubmed |
| pubmed-article:8436253 | pubmed:author | pubmed-author:AlbertiK GKG | lld:pubmed |
| pubmed-article:8436253 | pubmed:author | pubmed-author:ThomasT HTH | lld:pubmed |
| pubmed-article:8436253 | pubmed:author | pubmed-author:WilkinsonRR | lld:pubmed |
| pubmed-article:8436253 | pubmed:author | pubmed-author:WalkerMM | lld:pubmed |
| pubmed-article:8436253 | pubmed:author | pubmed-author:WinocourP HPH | lld:pubmed |
| pubmed-article:8436253 | pubmed:author | pubmed-author:CatalanoCC | lld:pubmed |
| pubmed-article:8436253 | pubmed:author | pubmed-author:SukC HCH | lld:pubmed |
| pubmed-article:8436253 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8436253 | pubmed:volume | 36 | lld:pubmed |
| pubmed-article:8436253 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8436253 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8436253 | pubmed:pagination | 52-6 | lld:pubmed |
| pubmed-article:8436253 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:8436253 | pubmed:meshHeading | pubmed-meshheading:8436253-... | lld:pubmed |
| pubmed-article:8436253 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8436253 | pubmed:articleTitle | Erythrocyte sodium-lithium countertransport activity and total body insulin-mediated glucose disposal in normoalbuminuric normotensive type 1 (insulin-dependent) diabetic patients. | lld:pubmed |
| pubmed-article:8436253 | pubmed:affiliation | Department of Medicine, University of Newcastle upon Tyne, UK. | lld:pubmed |
| pubmed-article:8436253 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8436253 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:8436253 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
