Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1993-3-15
pubmed:abstractText
In most bacteriophages of gram-negative bacteria, the phage endolysin is released to its murein substrate through a lesion in the inner membrane. The lesion is brought about by a second phage-encoded lysis function. For the first time, we present evidence that the same strategy is elaborated by a phage of a gram-positive bacterium. Thus, there appears to be an evolutionarily conserved lysis pathway for most phages whether their host bacterium is gram negative or gram positive. Phage phi 29 gene 14, the product of which is required for efficient lysis of Bacillus subtilis, was cloned in Escherichia coli. Production of protein 14 in E. coli resulted in cell death, whereas production of protein 14 concomitantly with the phi 29 lysozyme or unrelated murein-degrading enzymes led to lysis, suggesting that membrane-bound protein 14 induces a nonspecific lesion in the cytoplasmic membrane.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8432697-1406491, http://linkedlifedata.com/resource/pubmed/commentcorrection/8432697-2019562, http://linkedlifedata.com/resource/pubmed/commentcorrection/8432697-2023259, http://linkedlifedata.com/resource/pubmed/commentcorrection/8432697-2137120, http://linkedlifedata.com/resource/pubmed/commentcorrection/8432697-2138979, http://linkedlifedata.com/resource/pubmed/commentcorrection/8432697-2145264, http://linkedlifedata.com/resource/pubmed/commentcorrection/8432697-2147680, http://linkedlifedata.com/resource/pubmed/commentcorrection/8432697-2294085, http://linkedlifedata.com/resource/pubmed/commentcorrection/8432697-2402474, http://linkedlifedata.com/resource/pubmed/commentcorrection/8432697-2506424, http://linkedlifedata.com/resource/pubmed/commentcorrection/8432697-2531079, http://linkedlifedata.com/resource/pubmed/commentcorrection/8432697-2943725, http://linkedlifedata.com/resource/pubmed/commentcorrection/8432697-2965249, http://linkedlifedata.com/resource/pubmed/commentcorrection/8432697-2998005, http://linkedlifedata.com/resource/pubmed/commentcorrection/8432697-3027653, http://linkedlifedata.com/resource/pubmed/commentcorrection/8432697-3095189, http://linkedlifedata.com/resource/pubmed/commentcorrection/8432697-3469652, http://linkedlifedata.com/resource/pubmed/commentcorrection/8432697-3537305, http://linkedlifedata.com/resource/pubmed/commentcorrection/8432697-3597316, http://linkedlifedata.com/resource/pubmed/commentcorrection/8432697-3628006, http://linkedlifedata.com/resource/pubmed/commentcorrection/8432697-3803926, http://linkedlifedata.com/resource/pubmed/commentcorrection/8432697-4582731, http://linkedlifedata.com/resource/pubmed/commentcorrection/8432697-469991, http://linkedlifedata.com/resource/pubmed/commentcorrection/8432697-4939036, http://linkedlifedata.com/resource/pubmed/commentcorrection/8432697-6216243, http://linkedlifedata.com/resource/pubmed/commentcorrection/8432697-6217351, http://linkedlifedata.com/resource/pubmed/commentcorrection/8432697-6457237, http://linkedlifedata.com/resource/pubmed/commentcorrection/8432697-6460914, http://linkedlifedata.com/resource/pubmed/commentcorrection/8432697-731797, http://linkedlifedata.com/resource/pubmed/commentcorrection/8432697-820555
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0021-9193
pubmed:author
pubmed:issnType
Print
pubmed:volume
175
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1038-42
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
The missing link in phage lysis of gram-positive bacteria: gene 14 of Bacillus subtilis phage phi 29 encodes the functional homolog of lambda S protein.
pubmed:affiliation
Institute of Microbiology and Genetics, University of Vienna, Austria.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't