Linked Life Data

8432458

Source:http://linkedlifedata.com/resource/pubmed/id/8432458

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1993-3-16
pubmed:abstractText
The development of gap junctions in the human gastric mucosa has been examined to see if there is any relation to gastric ulcer. Freeze fracture replicas were prepared from the endoscopic biopsy specimens of 20 patients with gastric ulcer (15 men and five women, aged 49 (13) years) and seven healthy volunteers (four men and three women, aged 41 (19) years). Large fractured areas of lateral cell membranes of surface mucous cells were observed randomly at a direct magnification of 15,000 using electron microscopy. Small gap junctions were observed between gastric surface mucous cells in all healthy volunteers. Gap junctions in the patients with gastric ulcer were significantly fewer than in the healthy volunteers. In addition, gap junctions in patients with recurrent ulcer were significantly fewer than in those with first onset ulcer. There was no obvious relationship between age and the development of gap junctions in patients with gastric ulcer or in healthy volunteers. In areas of intestinal metaplasia, gap junctions were occasionally seen between absorptive cells of the villi, but not in the lateral membranes of goblet cells. These findings suggest that loss of intercellular communication via gap junctions is associated with gastric ulcer formation.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8432458-2337178, http://linkedlifedata.com/resource/pubmed/commentcorrection/8432458-2383884, http://linkedlifedata.com/resource/pubmed/commentcorrection/8432458-2494802, http://linkedlifedata.com/resource/pubmed/commentcorrection/8432458-2712338, http://linkedlifedata.com/resource/pubmed/commentcorrection/8432458-3721121, http://linkedlifedata.com/resource/pubmed/commentcorrection/8432458-6270711, http://linkedlifedata.com/resource/pubmed/commentcorrection/8432458-6359583, http://linkedlifedata.com/resource/pubmed/commentcorrection/8432458-641977, http://linkedlifedata.com/resource/pubmed/commentcorrection/8432458-6993412, http://linkedlifedata.com/resource/pubmed/commentcorrection/8432458-7032321, http://linkedlifedata.com/resource/pubmed/commentcorrection/8432458-838770
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0017-5749
pubmed:author
pubmed:issnType
Print
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
N
pubmed:pagination
86-9
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Electron microscopic study of intercellular junctions in human gastric mucosa with special reference to their relationship to gastric ulcer.
pubmed:affiliation
First Department of Internal Medicine, School of Medicine, Tokyo Medical and Dental University, Japan.
pubmed:publicationType
Journal Article, Comparative Study