Linked Life Data

8430602

Source:http://linkedlifedata.com/resource/pubmed/id/8430602

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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2 Pt 2
pubmed:dateCreated
1993-3-5
pubmed:abstractText
We investigated the effect of 1,4-dihydropyridine calcium antagonists (nifedipine, nisoldipine, and manidipine) on serotonin (5-hydroxytryptamine [5-HT])- and KCl (120 mmol/L)-induced contractions of rat isolated renal arcuate arteries. The preparation showed the well-known biphasic response to KCl-induced depolarization. All three calcium antagonists were more potent in inhibiting the second phase (tonic) compared with the first phase (transient) of the effect. The inhibitory concentration of 50% (pIC50) values were 6.92 +/- 0.24/8.51 +/- 0.08 (nifedipine, n = 32), 7.61 +/- 0.10/9.33 +/- 0.03 (nisoldipine, n = 28), and 7.61 +/- 0.13/9.07 +/- 0.06 (manidipine, n = 32) for the suppression of the first and second phases, respectively. In small coronary and renal arteries maximally activated with KCl solution, nifedipine and manidipine concentrations dependently inhibited the calcium concentration response curves. Manidipine was more potent than nifedipine (pIC50 coronary artery: 9.26 +/- 0.14 vs 7.93 +/- 0.22; pIC50 renal artery: 9.14 +/- 0.14 vs 7.77 +/- 0.21), but both compounds showed the same potency in the two different preparations. Furthermore, the influence of the calcium antagonists on the 5-HT concentration-response curve was investigated. Marked differences were found in the ability of the three compounds to inhibit the 5-HT-induced vasoconstriction of isolated renal arteries. For manidipine, a 93% +/- 3% reduction of the maximal 5-HT-induced contraction was observed, which was a significantly stronger inhibition compared with nifedipine (43% +/- 4.12%) or nisoldipine (26% +/- 0.37%). The pIC50 values were 7.96 +/- 0.15 (nifedipine), 8.17 +/- 0.14 (nisoldipine), and 7.84 +/- 0.12 (manidipine).(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0002-8703
pubmed:author
pubmed:issnType
Print
pubmed:volume
125
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
571-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Effects of manidipine and other calcium antagonists on rat renal arcuate arteries.
pubmed:affiliation
Department of Pharmacotherapy, University of Amsterdam, The Netherlands.
pubmed:publicationType
Journal Article, Comparative Study, In Vitro