Linked Life Data

8429556

Source:http://linkedlifedata.com/resource/pubmed/id/8429556

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1993-3-11
pubmed:abstractText
A procedure is described for estimating the probabilities for the backbone phi-psi angles of a protein molecule from the data base of known protein structures. The procedure is basically an adaptation of a published secondary structure prediction scheme, applied to the phi-psi angle bins rather than to the secondary types. The phi-psi angle probabilities estimated this way include all effects of local sequence and are "context sensitive" in that the probabilities for a given residue type depend on its position along the sequence. These probabilities can be used to predict the three-dimensional structure of short polypeptides that are stabilized mainly by local interactions only and to predict the protein folding initiation sites, with moderate to good success rates in each case. They are also potentially useful for efficient sampling in a Monte Carlo scheme of protein tertiary structure prediction methods.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0022-2836
pubmed:author
pubmed:issnType
Print
pubmed:day
20
pubmed:volume
229
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
448-60
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Estimation and use of protein backbone angle probabilities.
pubmed:affiliation
Physical Science Laboratory, National Institutes of Health, Bethesda, MD 20892.
pubmed:publicationType
Journal Article