| pubmed-article:8426119 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8426119 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:8426119 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:8426119 | lifeskim:mentions | umls-concept:C0028128 | lld:lifeskim |
| pubmed-article:8426119 | lifeskim:mentions | umls-concept:C0206190 | lld:lifeskim |
| pubmed-article:8426119 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:8426119 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:8426119 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:8426119 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8426119 | pubmed:dateCreated | 1993-3-1 | lld:pubmed |
| pubmed-article:8426119 | pubmed:abstractText | Preculture of thioglycollate-elicited C3HeB/FeJ mouse peritoneal macrophages in vitro with subthreshold stimulatory concentrations of lipopolysaccharide (LPS) can induce hyporesponsiveness (desensitization) to both tumor necrosis factor alpha (TNF-alpha) and nitric oxide (NO) production when these cells are subsequently stimulated with 100 ng/ml of LPS. We have established, however, that the primary dose of LPS required for inducing downregulation of NO production is significantly lower than that required for inducing downregulation of TNF-alpha production. Further, when LPS-pretreated macrophages become refractory to subsequent LPS stimulation for NO production, the secondary LPS-stimulated TNF-alpha production is markedly enhanced, and vice versa. These results indicate that LPS-induced TNF-alpha and NO production by macrophages are differentially regulated, and that the observed desensitization process may not reflect a state in which macrophages are totally refractory to subsequent LPS stimulation. Rather, our data suggest that LPS-pretreated macrophages become selectively primed for differential responses to LPS. The LPS-induced selective priming effects are not restricted to LPS stimulation, but extend as well to stimuli such as zymosan, Staphylococcus aureus, and heat-killed Listeria monocytogenes. | lld:pubmed |
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| pubmed-article:8426119 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8426119 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8426119 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8426119 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8426119 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:8426119 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:8426119 | pubmed:author | pubmed-author:MorrisonD CDC | lld:pubmed |
| pubmed-article:8426119 | pubmed:author | pubmed-author:ZhangXX | lld:pubmed |
| pubmed-article:8426119 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8426119 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8426119 | pubmed:volume | 177 | lld:pubmed |
| pubmed-article:8426119 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8426119 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8426119 | pubmed:pagination | 511-6 | lld:pubmed |
| pubmed-article:8426119 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8426119 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8426119 | pubmed:articleTitle | Lipopolysaccharide-induced selective priming effects on tumor necrosis factor alpha and nitric oxide production in mouse peritoneal macrophages. | lld:pubmed |
| pubmed-article:8426119 | pubmed:affiliation | Department of Microbiology, Molecular Genetics, and Immunology, University of Kansas Medical Center, Kansas City 66160. | lld:pubmed |
| pubmed-article:8426119 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8426119 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:8426119 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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