Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1993-2-24
pubmed:databankReference
pubmed:abstractText
Integrins play a central role in cellular adhesion and anchorage of the cytoskeleton and participate in the generation of intracellular signals, including tyrosine phosphorylation. We have recently isolated a cDNA encoding a unique, focal adhesion-associated protein tyrosine kinase (FAK) that is a component of an integrin-mediated signal transduction pathway. Here we report the isolation of cDNAs encoding the C-terminal, noncatalytic domain of the FAK kinase, termed FRNK (FAK-related nonkinase). Both the FAK- and FRNK-encoded polypeptides, pp125FAK and p41/p43FRNK, are expressed in normal chicken embryo cells. pp125FAK and p41/p43FRNK were localized to focal adhesions, suggesting that pp125FAK is directed to the focal adhesions by sequences within its C-terminal domain. We also show that the fibronectin-dependent increase in tyrosine phosphorylation of pp125FAK is accompanied by a concomitant posttranslational modification of p41FRNK.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8423801-1379699, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423801-1528852, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423801-1555235, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423801-1594631, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423801-1649385, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423801-1651913, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423801-1652767, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423801-1702789, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423801-1712734, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423801-1717976, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423801-1725602, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423801-1900302, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423801-1922035, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423801-1931088, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423801-1956339, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423801-1979172, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423801-2110361, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423801-2116421, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423801-2199285, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423801-2468126, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423801-2469003, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423801-2471744, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423801-2473404, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423801-2547805, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423801-2673543, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423801-271968, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423801-2928328, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423801-2938015, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423801-3041020, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423801-3115595, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423801-4831907, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423801-518835, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423801-5432063, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423801-6208378, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423801-6777776
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0270-7306
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
785-91
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Autonomous expression of a noncatalytic domain of the focal adhesion-associated protein tyrosine kinase pp125FAK.
pubmed:affiliation
Department of Microbiology and Cancer Center, University of Virginia Health Sciences Center, Charlottesville 22908.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't