Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1993-2-24
pubmed:abstractText
Vascular endothelial growth factor (VEGF) is a mitogen with a specificity for endothelial cells in vitro and an angiogenic inducer in vivo. We tested the hypothesis that VEGF may confer on expressing cells a growth advantage in vivo. Dihydrofolatereductase--Chinese hamster ovary cells were transfected with expression vectors which direct the constitutive synthesis of VEGF. Neither the expression nor the exogenous administration of VEGF stimulated anchorage-dependent or anchorage-independent growth of Chinese hamster ovary cells in vitro. However, VEGF-expressing clones, unlike control cells, demonstrated an ability to proliferate in nude mice. Histologic examination revealed that the proliferative lesions were compact, well vascularized, and nonedematous. Ultrastructural analysis revealed that capillaries within the lesions were of the continuous type. These findings indicate that the expression of VEGF may confer on cells the ability to grow in vivo in the absence of transformation by purely paracrine mechanisms. Since VEGF is a widely distributed protein, this property may have relevance for a variety of physiological and pathological proliferative processes.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8423215-13000707, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423215-1312256, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423215-1372863, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423215-1375931, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423215-1380254, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423215-1550962, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423215-1592003, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423215-1612003, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423215-1688381, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423215-1710435, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423215-1711045, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423215-1729274, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423215-1791186, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423215-1791831, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423215-1857232, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423215-1974323, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423215-2113573, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423215-2197082, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423215-2406719, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423215-2425435, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423215-2432664, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423215-2459969, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423215-2467210, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423215-2478587, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423215-2684646, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423215-2735925, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423215-2841120, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423215-3002607, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423215-3340164, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423215-3360856, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423215-3459590, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423215-3472348, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423215-3479675, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423215-3523756, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423215-3537791, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423215-3883191, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423215-5662020, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423215-6061717, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423215-6265188, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423215-6823562, http://linkedlifedata.com/resource/pubmed/commentcorrection/8423215-7412807
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0021-9738
pubmed:author
pubmed:issnType
Print
pubmed:volume
91
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
160-70
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
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