| pubmed-article:8422987 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8422987 | lifeskim:mentions | umls-concept:C0024554 | lld:lifeskim |
| pubmed-article:8422987 | lifeskim:mentions | umls-concept:C0015780 | lld:lifeskim |
| pubmed-article:8422987 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:8422987 | lifeskim:mentions | umls-concept:C1158770 | lld:lifeskim |
| pubmed-article:8422987 | lifeskim:mentions | umls-concept:C0013138 | lld:lifeskim |
| pubmed-article:8422987 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8422987 | pubmed:dateCreated | 1993-2-25 | lld:pubmed |
| pubmed-article:8422987 | pubmed:abstractText | The somatic sexual phenotype of Drosophila is regulated by the sexual differentiation pathway. Male (DSXM) and female (DSXF) proteins encoded by doublesex (dsx), a gene at the end of this pathway, bind to three sites within a 127-bp enhancer that directs sex- and tissue-specific transcription of Yolk protein genes. We describe mutagenesis of these binding sites and the resulting effects on DSXM and DSXF binding in vitro and on gene regulation in wild-type and dsx mutant flies. The results demonstrate that DSXM represses and DSXF activates transcription from the two strongest binding sites. Thus, the pathway regulates sex-specific transcription through the male and female dsx proteins that act directly on the target gene, but with opposite effects. | lld:pubmed |
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| pubmed-article:8422987 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:8422987 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8422987 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8422987 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:8422987 | pubmed:issn | 0890-9369 | lld:pubmed |
| pubmed-article:8422987 | pubmed:author | pubmed-author:WensinkP CPC | lld:pubmed |
| pubmed-article:8422987 | pubmed:author | pubmed-author:CoschiganoK... | lld:pubmed |
| pubmed-article:8422987 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8422987 | pubmed:volume | 7 | lld:pubmed |
| pubmed-article:8422987 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8422987 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8422987 | pubmed:pagination | 42-54 | lld:pubmed |
| pubmed-article:8422987 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:8422987 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8422987 | pubmed:articleTitle | Sex-specific transcriptional regulation by the male and female doublesex proteins of Drosophila. | lld:pubmed |
| pubmed-article:8422987 | pubmed:affiliation | Department of Biochemistry, Brandeis University, Waltham Massachusetts 02254-9110. | lld:pubmed |
| pubmed-article:8422987 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8422987 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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