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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1993-2-25
|
| pubmed:abstractText |
OBJECTIVE--To examine if the risk for CHD increases progressively with increases in the BMI of normoglycemic, hyperinsulinemic, morbidly obese women (BMI > or = 35 kg/m2). RESEARCH DESIGN AND METHODS--Insulin sensitivity was evaluated by calculating an ISI following an OGTT. There was a significant linear relationship between ISI and BMI fitted by two straight lines intersecting at a point corresponding to a BMI of 29.7 +/- 1.5 kg/m2. Significant linear relationships between insulin sensitivity and BMI were obtained below and above this breakpoint. Similarly, a breakpoint for the relation between dBP and BMI corresponding to a BMI > or = 33.7 +/- 3.4 kg/m2 was obtained. Significant linear relationships between BMI and plasma fasting glucose, triglyceride, cholesterol, HDL cholesterol, sBP, or dBP were not observed in the women with a BMI > 35 kg/m2. RESULTS--Compared with lean (BMI < 27) women of similar age, the morbidly obese patients appear to be at a higher risk for CHD. This is suggested by statistically significant increases in fasting insulin (mean +/- SD; 187 +/- 137 vs. 64.2 +/- 16.2 pM) and triglyceride levels (128 +/- 78.1 vs. 73 +/- 25 mg/dl), sBP (132 +/- 114 vs. 104 +/- 15.8) and dBP (84 +/- 72 vs. 67 +/- 2.1 mmHg), and decreases in HDL cholesterol (1.03 +/- 0.44 vs. 1.29 +/- 0.82 mM) and apo A-I (91 +/- 55 vs. 122 +/- 35 mg/dl) concentrations. CONCLUSIONS--It appears that there may be a threshold of body mass up to which insulin sensitivity is associated with CHD risk. Above this threshold, there does not appear to be a progressive increase in the risk factors for CHD with increases in BMI.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoprotein A-I,
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins B,
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, HDL,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Triglycerides
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0149-5992
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
16
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
144-9
|
| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:8422769-Adult,
pubmed-meshheading:8422769-Apolipoprotein A-I,
pubmed-meshheading:8422769-Apolipoproteins B,
pubmed-meshheading:8422769-Blood Glucose,
pubmed-meshheading:8422769-Blood Pressure,
pubmed-meshheading:8422769-Body Mass Index,
pubmed-meshheading:8422769-Body Weight,
pubmed-meshheading:8422769-Cholesterol,
pubmed-meshheading:8422769-Cholesterol, HDL,
pubmed-meshheading:8422769-Coronary Disease,
pubmed-meshheading:8422769-Female,
pubmed-meshheading:8422769-Glucose Tolerance Test,
pubmed-meshheading:8422769-Humans,
pubmed-meshheading:8422769-Hyperinsulinism,
pubmed-meshheading:8422769-Insulin,
pubmed-meshheading:8422769-Obesity, Morbid,
pubmed-meshheading:8422769-Reference Values,
pubmed-meshheading:8422769-Regression Analysis,
pubmed-meshheading:8422769-Risk Factors,
pubmed-meshheading:8422769-Triglycerides
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Coronary heart disease risk factors in morbidly obese women with normal glucose tolerance.
|
| pubmed:affiliation |
Department of Biochemistry, School of Medicine, East Carolina University, Greenville, North Carolina 27858-4354.
|
| pubmed:publicationType |
Journal Article,
Comparative Study
|