| pubmed-article:8422676 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8422676 | lifeskim:mentions | umls-concept:C0212694 | lld:lifeskim |
| pubmed-article:8422676 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:8422676 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:8422676 | lifeskim:mentions | umls-concept:C0124761 | lld:lifeskim |
| pubmed-article:8422676 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:8422676 | lifeskim:mentions | umls-concept:C0444930 | lld:lifeskim |
| pubmed-article:8422676 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8422676 | pubmed:dateCreated | 1993-2-24 | lld:pubmed |
| pubmed-article:8422676 | pubmed:abstractText | The DNA-dependent protein kinase (DNA-PK) phosphorylates Sp1 and several other nuclear proteins. Here, we show that Sp1 and the DNA-PK must be colocalized on the same DNA molecule for efficient phosphorylation to occur. Interestingly, we find that the DNA-PK binds to and is activated by the ends of DNA molecules. Furthermore, we show that the DNA binding properties of the DNA-PK are identical to those of Ku, a well-characterized human autoimmune antigen. We demonstrate that the DNA-PK can be fractionated into two components, one of which is Ku and the other of which is a polypeptide of approximately 350 kd. DNA cross-linking and coimmunoprecipitation studies indicate that the catalytic 350 kd DNA-PK component is directed to DNA by protein-protein interactions with Ku. The implications of the unusual DNA binding mode and multicomponent nature of the DNA-PK are discussed. | lld:pubmed |
| pubmed-article:8422676 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8422676 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:8422676 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8422676 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8422676 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:8422676 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:8422676 | pubmed:author | pubmed-author:JacksonS PSP | lld:pubmed |
| pubmed-article:8422676 | pubmed:author | pubmed-author:GottliebT MTM | lld:pubmed |
| pubmed-article:8422676 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8422676 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:8422676 | pubmed:volume | 72 | lld:pubmed |
| pubmed-article:8422676 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8422676 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8422676 | pubmed:pagination | 131-42 | lld:pubmed |
| pubmed-article:8422676 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:8422676 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8422676 | pubmed:articleTitle | The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen. | lld:pubmed |
| pubmed-article:8422676 | pubmed:affiliation | Wellcome/CRC Institute, Cambridge, England. | lld:pubmed |
| pubmed-article:8422676 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8422676 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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