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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1993-2-22
|
| pubmed:abstractText |
Apolipoprotein (apo) A-IV has been proposed to play a role in reverse cholesterol transport. ApoA-IV-containing lipoprotein particles (A-IVLp) were isolated from human plasma and interstitial fluid and characterized by immunoaffinity chromatography. Two major A-IVLp subpopulations, lipoprotein particles containing apoA-IV with apoA-I (LpA-I:A-IV) and lipoprotein particles containing apoA-IV without apoA-I (LpA-IV), were identified. The larger subpopulation of A-IVLp is the LpA-IV that represents 70% (protein mass) of the initial particles. Only 5.8% of apoA-IV was recovered in the retained fraction after affinity chromatography with an anti-apoA-I immunosorbent. ApoA-I, apoA-II, apoA-IV, apoB, apoC-III, apoD, apoE, apoH, lecithin: cholesterol acyltransferase (LCAT), cholesteryl ester transfer (CET) protein, proline-rich protein, and a protein of Mr 59,000 were detected in the A-IVLp. These particles contain more than 20% triglycerides (lipid mass). ApoA-IV-containing particles that were isolated from plasma are heterogeneous in size, consisting of two major populations with Stokes' diameters of 10.3 nm and 9.3 nm. Both subpopulations of A-IVLp contain LCAT and CET activities and promote cholesterol efflux from cholesterol-preloaded adipose cells. These data support the hypothesis that A-IVLp particles may be involved in reverse cholesterol transport.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins A,
http://linkedlifedata.com/resource/pubmed/chemical/Blood Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/CETP protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol Ester Transfer Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylcholine-Sterol...,
http://linkedlifedata.com/resource/pubmed/chemical/apolipoprotein A-IV
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
1049-8834
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
13
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
126-32
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:8422335-Adipose Tissue,
pubmed-meshheading:8422335-Adult,
pubmed-meshheading:8422335-Apolipoproteins A,
pubmed-meshheading:8422335-Blood Proteins,
pubmed-meshheading:8422335-Carrier Proteins,
pubmed-meshheading:8422335-Cell Line,
pubmed-meshheading:8422335-Chemical Phenomena,
pubmed-meshheading:8422335-Chemistry,
pubmed-meshheading:8422335-Cholesterol,
pubmed-meshheading:8422335-Cholesterol Ester Transfer Proteins,
pubmed-meshheading:8422335-Chromatography, Affinity,
pubmed-meshheading:8422335-Chromatography, Gel,
pubmed-meshheading:8422335-Extracellular Space,
pubmed-meshheading:8422335-Glycoproteins,
pubmed-meshheading:8422335-Humans,
pubmed-meshheading:8422335-Immunologic Techniques,
pubmed-meshheading:8422335-Phosphatidylcholine-Sterol O-Acyltransferase,
pubmed-meshheading:8422335-Stem Cells
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Characterization of apoA-IV-containing lipoprotein particles isolated from human plasma and interstitial fluid.
|
| pubmed:affiliation |
Institut Pasteur, INSERM, Lille, France.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|