pubmed-article:8419084 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:8419084 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
pubmed-article:8419084 | lifeskim:mentions | umls-concept:C0015024 | lld:lifeskim |
pubmed-article:8419084 | lifeskim:mentions | umls-concept:C0229671 | lld:lifeskim |
pubmed-article:8419084 | lifeskim:mentions | umls-concept:C0002199 | lld:lifeskim |
pubmed-article:8419084 | lifeskim:mentions | umls-concept:C0068527 | lld:lifeskim |
pubmed-article:8419084 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
pubmed-article:8419084 | lifeskim:mentions | umls-concept:C0333516 | lld:lifeskim |
pubmed-article:8419084 | lifeskim:mentions | umls-concept:C0442818 | lld:lifeskim |
pubmed-article:8419084 | pubmed:issue | 1 | lld:pubmed |
pubmed-article:8419084 | pubmed:dateCreated | 1993-2-8 | lld:pubmed |
pubmed-article:8419084 | pubmed:abstractText | Serum levels of tumour necrosis factor-alpha (TNF-alpha), neopterin and interferon-alpha (IFN-alpha) were determined by immunoradiometric assays in 60 HIV-1+ and 20 HIV-1- subjects from Ethiopia. Swedish samples were used as reference material. The Ethiopian HIV-1+ subjects were found to have significantly increased TNF-alpha and neopterin, but not IFN-alpha levels. Increased levels of TNF-alpha and neopterin were frequently found in Ethiopian asymptomatic subjects (37% and 47%), and the concentration increased in patients with AIDS (83% and 90% respectively). The levels of the two substances and the proportion of patients with higher TNF-alpha values were lower in the corresponding Swedish subjects. The proportion of sera with raised levels of IFN-alpha was very low (asymptomatic 4%, and AIDS 7%) in Ethiopian subjects. These results suggest a very early increase in the TNF-alpha production and activation of the cellular immune response, and a low level of IFN-alpha synthesis in the natural course of HIV infection in Ethiopia. The aberrations may contribute to a rapid progress of immunodeficiency and cachexia often seen in Ethiopian patients. | lld:pubmed |
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pubmed-article:8419084 | pubmed:language | eng | lld:pubmed |
pubmed-article:8419084 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8419084 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:8419084 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:8419084 | pubmed:month | Jan | lld:pubmed |
pubmed-article:8419084 | pubmed:issn | 0009-9104 | lld:pubmed |
pubmed-article:8419084 | pubmed:author | pubmed-author:BrittonSS | lld:pubmed |
pubmed-article:8419084 | pubmed:author | pubmed-author:StrannegardOO | lld:pubmed |
pubmed-article:8419084 | pubmed:author | pubmed-author:AyehunieSS | lld:pubmed |
pubmed-article:8419084 | pubmed:author | pubmed-author:ZewdieD WDW | lld:pubmed |
pubmed-article:8419084 | pubmed:author | pubmed-author:Yemane-Berhan... | lld:pubmed |
pubmed-article:8419084 | pubmed:author | pubmed-author:SonnerborgAA | lld:pubmed |
pubmed-article:8419084 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:8419084 | pubmed:volume | 91 | lld:pubmed |
pubmed-article:8419084 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:8419084 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:8419084 | pubmed:pagination | 37-42 | lld:pubmed |
pubmed-article:8419084 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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pubmed-article:8419084 | pubmed:year | 1993 | lld:pubmed |
pubmed-article:8419084 | pubmed:articleTitle | Raised levels of tumour necrosis factor-alpha and neopterin, but not interferon-alpha, in serum of HIV-1-infected patients from Ethiopia. | lld:pubmed |
pubmed-article:8419084 | pubmed:affiliation | Department of Biology, Addis Ababa University, Ethiopia. | lld:pubmed |
pubmed-article:8419084 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:8419084 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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