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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1993-2-8
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pubmed:abstractText |
Serum levels of tumour necrosis factor-alpha (TNF-alpha), neopterin and interferon-alpha (IFN-alpha) were determined by immunoradiometric assays in 60 HIV-1+ and 20 HIV-1- subjects from Ethiopia. Swedish samples were used as reference material. The Ethiopian HIV-1+ subjects were found to have significantly increased TNF-alpha and neopterin, but not IFN-alpha levels. Increased levels of TNF-alpha and neopterin were frequently found in Ethiopian asymptomatic subjects (37% and 47%), and the concentration increased in patients with AIDS (83% and 90% respectively). The levels of the two substances and the proportion of patients with higher TNF-alpha values were lower in the corresponding Swedish subjects. The proportion of sera with raised levels of IFN-alpha was very low (asymptomatic 4%, and AIDS 7%) in Ethiopian subjects. These results suggest a very early increase in the TNF-alpha production and activation of the cellular immune response, and a low level of IFN-alpha synthesis in the natural course of HIV infection in Ethiopia. The aberrations may contribute to a rapid progress of immunodeficiency and cachexia often seen in Ethiopian patients.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8419084-1503684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8419084-1673120,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8419084-1796553,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8419084-1901653,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8419084-1906289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8419084-1967191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8419084-1971915,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8419084-2300561,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8419084-2304140,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8419084-2324549,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8419084-2335821,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8419084-2413547,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8419084-2468718,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8419084-2470148,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8419084-2582258,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8419084-2667296,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8419084-2783972,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8419084-2784570,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8419084-2789293,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8419084-2806917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8419084-2877346,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8419084-3010124,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8419084-3017711,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8419084-3022379,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8419084-3076770,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8419084-3108447,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8419084-3277271,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8419084-3414726,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8419084-3440464,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8419084-3760569,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8419084-3872925,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8419084-7119475
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
91
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
37-42
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8419084-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:8419084-Adolescent,
pubmed-meshheading:8419084-Adult,
pubmed-meshheading:8419084-Biopterin,
pubmed-meshheading:8419084-Ethiopia,
pubmed-meshheading:8419084-Female,
pubmed-meshheading:8419084-HIV-1,
pubmed-meshheading:8419084-Humans,
pubmed-meshheading:8419084-Interferon-alpha,
pubmed-meshheading:8419084-Male,
pubmed-meshheading:8419084-Middle Aged,
pubmed-meshheading:8419084-Neopterin,
pubmed-meshheading:8419084-Tumor Necrosis Factor-alpha
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pubmed:year |
1993
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pubmed:articleTitle |
Raised levels of tumour necrosis factor-alpha and neopterin, but not interferon-alpha, in serum of HIV-1-infected patients from Ethiopia.
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pubmed:affiliation |
Department of Biology, Addis Ababa University, Ethiopia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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