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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1993-2-2
|
| pubmed:abstractText |
In 70 consecutive patients with symptoms of gastroesophageal reflux (GER), we studied lower esophageal sphincter (LES) and upper esophageal sphincter (UES) pressures, esophageal peristalsis, and esophageal acid exposure 5 and 20 cm above the LES. Based on the percentage of time the pH was below 4 in the proximal esophagus, the patients were divided into 2 groups: (1) group A, less than 3%, 48 patients; (2) group B, greater than 3%, 22 patients. LES was weaker (13.5 +/- 6.0 mm Hg in group A versus 7.8 +/- 4.6 mm Hg in group B) and shorter (2.2 +/- 0.7 cm in group A versus 1.5 +/- 0.5 cm in group B) in group B patients. Group B patients also had lower amplitude of peristalsis in the proximal (59.2 +/- 17.6 mm Hg in group A versus 42.4 +/- 18 mm Hg in group B) and distal esophagus (89.7 +/- 25.2 mm Hg in group A versus 54.7 +/- 27.9 mm Hg in group B) and lower UES pressures (73.7 +/- 30.7 mm Hg in group A versus 54.7 +/- 29.3 mm Hg in group B). Forty-one percent of group B patients had pulmonary aspiration, whereas only 2% of the patients in group A experienced pulmonary aspiration. These data show that, in a subgroup of patients with symptoms of GER, the upper esophagus is exposed to acid for more than 3% of the time. Patients with high GER differ clinically and pathophysiologically from those in whom reflux is limited to the distal part of the esophagus: those with high GER have a panesophageal motor dysfunction and a high risk of aspiration.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0002-9610
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
165
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
163-6; discussion 166-8
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:8418693-Esophagitis, Peptic,
pubmed-meshheading:8418693-Esophagogastric Junction,
pubmed-meshheading:8418693-Esophagus,
pubmed-meshheading:8418693-Female,
pubmed-meshheading:8418693-Gastroesophageal Reflux,
pubmed-meshheading:8418693-Humans,
pubmed-meshheading:8418693-Hydrogen-Ion Concentration,
pubmed-meshheading:8418693-Male,
pubmed-meshheading:8418693-Manometry,
pubmed-meshheading:8418693-Middle Aged,
pubmed-meshheading:8418693-Peristalsis,
pubmed-meshheading:8418693-Prospective Studies,
pubmed-meshheading:8418693-Risk Factors,
pubmed-meshheading:8418693-Time Factors
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Clinical and functional characterization of high gastroesophageal reflux.
|
| pubmed:affiliation |
Department of Surgery, University of California, San Francisco.
|
| pubmed:publicationType |
Journal Article
|