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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1993-1-29
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pubmed:abstractText |
The epidemiology of pulmonary colonisation by Pseudomonas aeruginosa was studied in 21 patients with cystic fibrosis (CF) by field inversion gel electrophoresis. DraI-DNA restriction patterns were analysed for 187 P. aeruginosa isolates from these patients. The results revealed that the strains present in individual patients varied during the course of chronic colonisation; the emergence of new strains often was associated with periods of antibiotic therapy. Patients often were colonised by more than one strain (two or three strains were present in 54% of the patients) and the strains obtained from unrelated patients were highly heterogeneous, in contrast to those isolated from a pair of twins. These results demonstrate the heterogeneity and variability of P. aeruginosa isolates in the pulmonary flora of chronically infected CF patients.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-2615
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
38
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
29-33
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pubmed:dateRevised |
2008-8-28
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pubmed:meshHeading |
pubmed-meshheading:8418289-Adolescent,
pubmed-meshheading:8418289-Adult,
pubmed-meshheading:8418289-Anti-Bacterial Agents,
pubmed-meshheading:8418289-Carrier State,
pubmed-meshheading:8418289-Child,
pubmed-meshheading:8418289-Child, Preschool,
pubmed-meshheading:8418289-Chronic Disease,
pubmed-meshheading:8418289-Cystic Fibrosis,
pubmed-meshheading:8418289-DNA, Bacterial,
pubmed-meshheading:8418289-Deoxyribonucleases, Type II Site-Specific,
pubmed-meshheading:8418289-Electrophoresis, Agar Gel,
pubmed-meshheading:8418289-Female,
pubmed-meshheading:8418289-Humans,
pubmed-meshheading:8418289-Male,
pubmed-meshheading:8418289-Pseudomonas Infections,
pubmed-meshheading:8418289-Pseudomonas aeruginosa,
pubmed-meshheading:8418289-Restriction Mapping,
pubmed-meshheading:8418289-Sputum
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pubmed:year |
1993
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pubmed:articleTitle |
Molecular epidemiology of chronic pulmonary colonisation by Pseudomonas aeruginosa in cystic fibrosis.
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pubmed:affiliation |
Laboratoire de Microbiologie, Hôpital Necker-Enfants Malades, Paris, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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