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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1993-1-27
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pubmed:abstractText |
Pig-1 and Sgs-4 are a pair of closely linked and divergently transcribed Drosophila melanogaster genes, which are both expressed in larval salivary glands but at different times during development. While Sgs-4 is expressed at high levels only at the end of the third instar, Pig-1 exhibits a major peak of expression during late second and early third instar. Thus, Pig-1 expression declines as Sgs-4 expression is induced. In this paper, we show that three adjacent elements located within the short region between these genes can account for the switch from Pig-1 to Sgs-4 expression. A 170-bp segment acts as an enhancer to direct Sgs-4 expression in late-third-instar salivary glands. A 64-bp sequence located just upstream from the enhancer can modify its temporal specificity so that it works throughout the third instar. Expression induced at mid-third instar by a combination of these two elements can be repressed by a negative regulatory sequence located still further upstream. We present evidence suggesting that the changing interactions between these regulatory elements and the Sgs-4 and Pig-1 promoters lead to the correct pattern of expression of the two genes.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8417325-1577269,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8417325-16453749,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8417325-1683847,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8417325-1695584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8417325-1702902,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8417325-1743483,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/8417325-1903838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8417325-1936956,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8417325-1978325,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/8417325-2113880,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8417325-2322462,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8417325-2423251,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/8417325-2516829,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8417325-2606354,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8417325-2792089,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8417325-2848550,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8417325-2942397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8417325-3007005,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/8417325-3167976,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/8417325-3362860,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/8417325-3919395,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8417325-4198832,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8417325-6091052,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8417325-6172303,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8417325-6207936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8417325-6279311,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8417325-6289436,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8417325-6312420,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8417325-6411930,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8417325-6784121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8417325-812097,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8417325-825230
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0270-7306
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
13
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pubmed:geneSymbol |
Pig-1,
Sgs-4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
184-95
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pubmed:dateRevised |
2010-9-13
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pubmed:meshHeading |
pubmed-meshheading:8417325-Age Factors,
pubmed-meshheading:8417325-Animals,
pubmed-meshheading:8417325-Drosophila melanogaster,
pubmed-meshheading:8417325-Enhancer Elements, Genetic,
pubmed-meshheading:8417325-Gene Expression Regulation,
pubmed-meshheading:8417325-Genes, Insect,
pubmed-meshheading:8417325-Glue Proteins, Drosophila,
pubmed-meshheading:8417325-Larva,
pubmed-meshheading:8417325-Pupa,
pubmed-meshheading:8417325-RNA, Messenger,
pubmed-meshheading:8417325-Regulatory Sequences, Nucleic Acid,
pubmed-meshheading:8417325-Salivary Glands,
pubmed-meshheading:8417325-Salivary Proteins and Peptides,
pubmed-meshheading:8417325-Transcription, Genetic
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pubmed:year |
1993
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pubmed:articleTitle |
A transcriptional switch between the Pig-1 and Sgs-4 genes of Drosophila melanogaster.
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pubmed:affiliation |
Department of Molecular and Cell Biology, University of California, Berkeley 94720.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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