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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1993-1-25
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pubmed:abstractText |
Study of transmembrane signaling via G proteins has focused to a large extent upon investigations of individual G protein-linked receptor-effector systems. Agonist-induced desensitization and down-regulation of beta-adrenergic receptors, for example, have been studied extensively and adopted as a general model for G protein-linked receptor regulation. This review focuses not only on agonist regulation of adrenergic receptor gene expression, but also on how agonists regulate opposing adrenergic receptor-mediated pathways. This important feature of G protein-mediated pathways, i.e., cross-regulation and integration of information among several pathways, will be discussed in the context of what has been learned in the adrenergic receptor-coupled pathways.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-3042
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1-9
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:8417134-Adenylate Cyclase,
pubmed-meshheading:8417134-Animals,
pubmed-meshheading:8417134-GTP-Binding Proteins,
pubmed-meshheading:8417134-Gene Expression Regulation,
pubmed-meshheading:8417134-Humans,
pubmed-meshheading:8417134-Receptors, Adrenergic,
pubmed-meshheading:8417134-Stimulation, Chemical,
pubmed-meshheading:8417134-Type C Phospholipases
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pubmed:year |
1993
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pubmed:articleTitle |
Agonist regulation of gene expression of adrenergic receptors and G proteins.
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pubmed:affiliation |
Department of Molecular Pharmacology, School of Medicine, SUNY/Stony Brook 11794-8651.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Review,
Research Support, Non-U.S. Gov't
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