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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1993-1-21
|
| pubmed:abstractText |
This study evaluated the efficacy of a single dose of intramuscular ceftriaxone for acute otitis media in children, using amoxicillin as a control. (There is currently no established single-dose treatment for this condition.) In a prospective, randomized, double-blind, clinical trial, 233 children, aged 5 months to 5 years, with uncomplicated acute otitis media were randomly assigned to receive either a single intramuscular injection of ceftriaxone (50 mg/kg) plus placebo oral suspension for 10 days, or a placebo injection plus amoxicillin oral suspension (40 mg/kg per day divided three times per day) for 10 days in a double-blind fashion. Demographic and clinical characteristics were similar in both groups. Treatment was successful in 107 of 117 given amoxicillin (91%, 95% confidence interval 86% to 97%) and 105 of 116 given ceftriaxone (91%, 95% confidence interval 85% to 96%). Rates of improvement, failure, relapse, and reinfection were similar in both groups, as were the otoscopic and tympanometric evaluations at the 14- and 60-day follow-up visits. It is concluded that a single intramuscular injection of ceftriaxone (50 mg/kg) is as effective as 10 days of oral amoxicillin for the treatment of uncomplicated acute otitis media in children.
|
| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0031-4005
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
91
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
23-30
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8416502-Acoustic Impedance Tests,
pubmed-meshheading:8416502-Acute Disease,
pubmed-meshheading:8416502-Amoxicillin,
pubmed-meshheading:8416502-Ceftriaxone,
pubmed-meshheading:8416502-Child,
pubmed-meshheading:8416502-Child, Preschool,
pubmed-meshheading:8416502-Double-Blind Method,
pubmed-meshheading:8416502-Drug Costs,
pubmed-meshheading:8416502-Female,
pubmed-meshheading:8416502-Humans,
pubmed-meshheading:8416502-Infant,
pubmed-meshheading:8416502-Injections, Intramuscular,
pubmed-meshheading:8416502-Male,
pubmed-meshheading:8416502-Otitis Media,
pubmed-meshheading:8416502-Prospective Studies,
pubmed-meshheading:8416502-Recurrence,
pubmed-meshheading:8416502-Treatment Failure,
pubmed-meshheading:8416502-Treatment Outcome
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Single-dose intramuscular ceftriaxone for acute otitis media in children.
|
| pubmed:affiliation |
Dept of Emergency Medicine, Riverside General Hospital, CA 92503.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|