Linked Life Data

8415936

Source:http://linkedlifedata.com/resource/pubmed/id/8415936

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1993-11-16
pubmed:abstractText
We examined the relative contribution of dopamine (DA) receptors in the brain and periphery in the control of sham and real feeding of sucrose solutions. Intraperitoneal (IP) administration of pimozide, an antagonist of peripheral and brain DA receptors, suppressed both sham and real feeding in a dose-related manner. In contrast, IP injections of domperidone, a DA antagonist restricted to peripheral receptors, had no effect on either sham or real feeding. The inability of domperidone to influence sucrose intake did not result from a lack of biological activity of the drug because the identical doses of domperidone that failed to alter eating significantly inhibited gastric acid secretion. The results implicate central, but not peripheral, DA receptors in the control of the ingestion of palatable foods and also suggest that sham feeding is more sensitive to DA antagonism than real feeding.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0031-9384
pubmed:author
pubmed:issnType
Print
pubmed:volume
54
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
449-54
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Dopamine antagonists act on central, but not peripheral, receptors to inhibit sham and real feeding.
pubmed:affiliation
Department of Psychology, McMaster University, Hamilton, Ontario, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't