Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1993-10-26
|
| pubmed:abstractText |
Pretreatment with the serotonin-3 (5-HT3) antagonist racemic (+/-)-Zacopride hydrochloride (ZAC, 0.1 mg/kg, IP) has been previously found to completely abolish the locomotor activity induced by cocaine (10 mg/kg, IP). To determine if this effect was mediated by fluctuations in the extracellular levels of forebrain dopamine (DA), we examined the ability of ZAC to attenuate cocaine-induced increases in extracellular DA levels. Microdialysis samples were collected from the nucleus accumbens region (NAS) of awake, male, Sprague-Dawley rats. ZAC treatment alone (0.1 mg/kg, IP) did not alter DA levels relative to baseline. However, this dose of ZAC given 1 h prior to cocaine challenge (10 mg/kg, IP) caused a 27% reduction in the peak level of extracellular DA produced by cocaine, relative to saline-pretreated control animals. These results suggest that the ability of ZAC to attenuate cocaine-induced increases in extracellular DA levels may contribute to ZAC's ability to suppress cocaine-induced locomotor activity in the rat. However, additional neurochemical mechanisms are likely to be important in mediating the robust behavioral effects previously reported.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3,4-Dihydroxyphenylacetic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Benzamides,
http://linkedlifedata.com/resource/pubmed/chemical/Bicyclo Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Bicyclo Compounds, Heterocyclic,
http://linkedlifedata.com/resource/pubmed/chemical/Cocaine,
http://linkedlifedata.com/resource/pubmed/chemical/Homovanillic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/zacopride
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0091-3057
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
45
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
759-63
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:8415815-3,4-Dihydroxyphenylacetic Acid,
pubmed-meshheading:8415815-Animals,
pubmed-meshheading:8415815-Benzamides,
pubmed-meshheading:8415815-Bicyclo Compounds,
pubmed-meshheading:8415815-Bicyclo Compounds, Heterocyclic,
pubmed-meshheading:8415815-Chromatography, High Pressure Liquid,
pubmed-meshheading:8415815-Cocaine,
pubmed-meshheading:8415815-Dialysis,
pubmed-meshheading:8415815-Dopamine,
pubmed-meshheading:8415815-Extracellular Space,
pubmed-meshheading:8415815-Homovanillic Acid,
pubmed-meshheading:8415815-Male,
pubmed-meshheading:8415815-Motor Activity,
pubmed-meshheading:8415815-Nucleus Accumbens,
pubmed-meshheading:8415815-Prosencephalon,
pubmed-meshheading:8415815-Rats,
pubmed-meshheading:8415815-Rats, Sprague-Dawley,
pubmed-meshheading:8415815-Serotonin Antagonists
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
The 5-HT3 antagonist zacopride attenuates cocaine-induced increases in extracellular dopamine in rat nucleus accumbens.
|
| pubmed:affiliation |
Department of Psychiatry and Behavioral Science, State University of New York, Stony Brook 11794-8790.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|