| pubmed-article:8415749 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8415749 | lifeskim:mentions | umls-concept:C0086661 | lld:lifeskim |
| pubmed-article:8415749 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:8415749 | lifeskim:mentions | umls-concept:C0332197 | lld:lifeskim |
| pubmed-article:8415749 | lifeskim:mentions | umls-concept:C0333516 | lld:lifeskim |
| pubmed-article:8415749 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:8415749 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:8415749 | lifeskim:mentions | umls-concept:C1156237 | lld:lifeskim |
| pubmed-article:8415749 | lifeskim:mentions | umls-concept:C1159884 | lld:lifeskim |
| pubmed-article:8415749 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:8415749 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:8415749 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:8415749 | pubmed:issue | 20 | lld:pubmed |
| pubmed-article:8415749 | pubmed:dateCreated | 1993-11-19 | lld:pubmed |
| pubmed-article:8415749 | pubmed:abstractText | Tumor necrosis factor (TNF) inhibits and reverses differentiation of mouse adipogenic TA1 cells. We have found that TNF induces c-myc in a sustained manner in both preadipocytes and adipocytes; in contrast, serum induces c-myc transiently and only in preadipocytes. This TNF-mediated c-myc induction is not coupled with cell proliferation but is correlated with TNF-mediated inhibition of adipocyte differentiation. We prepared an inducible c-myc transformant of TA1 cells by transfection of the mouse c-myc gene under the control of the metallothionein-I promoter. These cells are unable to differentiate to adipocytes in the presence of Zn2+/Cd2+, and in differentiated TA1 cells, Zn2+/Cd2+ causes reduction of adipocyte-specific gene expression as does TNF. Lastly, exposure of TA1 cells to antisense c-myc oligonucleotide partially blocked the TNF-mediated reduction of adipocyte-specific gene expression. Thus, TNF-mediated c-myc expression is distinct in character from that involved in mitogenic responses but appears to play an important role in inhibition and reversal of adipocyte differentiation. | lld:pubmed |
| pubmed-article:8415749 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8415749 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8415749 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8415749 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8415749 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8415749 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8415749 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8415749 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8415749 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8415749 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8415749 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8415749 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8415749 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8415749 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8415749 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8415749 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8415749 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8415749 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8415749 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8415749 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8415749 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8415749 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8415749 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8415749 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8415749 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8415749 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8415749 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8415749 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8415749 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8415749 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8415749 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8415749 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8415749 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8415749 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8415749 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8415749 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8415749 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8415749 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8415749 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8415749 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8415749 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8415749 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8415749 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8415749 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8415749 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8415749 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:8415749 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:8415749 | pubmed:author | pubmed-author:RingoldG MGM | lld:pubmed |
| pubmed-article:8415749 | pubmed:author | pubmed-author:TortoF GFG | lld:pubmed |
| pubmed-article:8415749 | pubmed:author | pubmed-author:Ninomiya-Tsuj... | lld:pubmed |
| pubmed-article:8415749 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8415749 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:8415749 | pubmed:volume | 90 | lld:pubmed |
| pubmed-article:8415749 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8415749 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8415749 | pubmed:pagination | 9611-5 | lld:pubmed |
| pubmed-article:8415749 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:8415749 | pubmed:meshHeading | pubmed-meshheading:8415749-... | lld:pubmed |
| pubmed-article:8415749 | pubmed:meshHeading | pubmed-meshheading:8415749-... | lld:pubmed |
| pubmed-article:8415749 | pubmed:meshHeading | pubmed-meshheading:8415749-... | lld:pubmed |
| pubmed-article:8415749 | pubmed:meshHeading | pubmed-meshheading:8415749-... | lld:pubmed |
| pubmed-article:8415749 | pubmed:meshHeading | pubmed-meshheading:8415749-... | lld:pubmed |
| pubmed-article:8415749 | pubmed:meshHeading | pubmed-meshheading:8415749-... | lld:pubmed |
| pubmed-article:8415749 | pubmed:meshHeading | pubmed-meshheading:8415749-... | lld:pubmed |
| pubmed-article:8415749 | pubmed:meshHeading | pubmed-meshheading:8415749-... | lld:pubmed |
| pubmed-article:8415749 | pubmed:meshHeading | pubmed-meshheading:8415749-... | lld:pubmed |
| pubmed-article:8415749 | pubmed:meshHeading | pubmed-meshheading:8415749-... | lld:pubmed |
| pubmed-article:8415749 | pubmed:meshHeading | pubmed-meshheading:8415749-... | lld:pubmed |
| pubmed-article:8415749 | pubmed:meshHeading | pubmed-meshheading:8415749-... | lld:pubmed |
| pubmed-article:8415749 | pubmed:meshHeading | pubmed-meshheading:8415749-... | lld:pubmed |
| pubmed-article:8415749 | pubmed:meshHeading | pubmed-meshheading:8415749-... | lld:pubmed |
| pubmed-article:8415749 | pubmed:meshHeading | pubmed-meshheading:8415749-... | lld:pubmed |
| pubmed-article:8415749 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8415749 | pubmed:articleTitle | Tumor necrosis factor-induced c-myc expression in the absence of mitogenesis is associated with inhibition of adipocyte differentiation. | lld:pubmed |
| pubmed-article:8415749 | pubmed:affiliation | Affymax Research Institute, Palo Alto, CA 94304. | lld:pubmed |
| pubmed-article:8415749 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8415749 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:8415749 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8415749 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8415749 | lld:pubmed |
