|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0086661,
umls-concept:C0185117,
umls-concept:C0332197,
umls-concept:C0332281,
umls-concept:C0333516,
umls-concept:C1156237,
umls-concept:C1159884,
umls-concept:C2911684
|
|
pubmed:issue |
20
|
|
pubmed:dateCreated |
1993-11-19
|
|
pubmed:abstractText |
Tumor necrosis factor (TNF) inhibits and reverses differentiation of mouse adipogenic TA1 cells. We have found that TNF induces c-myc in a sustained manner in both preadipocytes and adipocytes; in contrast, serum induces c-myc transiently and only in preadipocytes. This TNF-mediated c-myc induction is not coupled with cell proliferation but is correlated with TNF-mediated inhibition of adipocyte differentiation. We prepared an inducible c-myc transformant of TA1 cells by transfection of the mouse c-myc gene under the control of the metallothionein-I promoter. These cells are unable to differentiate to adipocytes in the presence of Zn2+/Cd2+, and in differentiated TA1 cells, Zn2+/Cd2+ causes reduction of adipocyte-specific gene expression as does TNF. Lastly, exposure of TA1 cells to antisense c-myc oligonucleotide partially blocked the TNF-mediated reduction of adipocyte-specific gene expression. Thus, TNF-mediated c-myc expression is distinct in character from that involved in mitogenic responses but appears to play an important role in inhibition and reversal of adipocyte differentiation.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415749-1321348,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415749-1339452,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415749-1385853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415749-1411535,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415749-1508226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415749-1535827,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415749-1566086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415749-1618860,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415749-1638116,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415749-1658188,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415749-1729273,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415749-1833648,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415749-1899225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415749-1935900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415749-1939208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415749-1987644,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415749-2006196,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415749-2016326,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415749-2454393,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415749-2524830,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415749-2537468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415749-2606350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415749-2827008,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415749-2921280,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415749-2983194,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415749-3280975,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415749-3497923,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415749-3839597,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415749-3915782,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415749-518835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415749-6321164,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415749-6392298,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415749-7254320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415749-8436824
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
0027-8424
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
90
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
9611-5
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:8415749-Adipocytes,
pubmed-meshheading:8415749-Base Sequence,
pubmed-meshheading:8415749-Cell Differentiation,
pubmed-meshheading:8415749-Cells, Cultured,
pubmed-meshheading:8415749-Gene Expression Regulation,
pubmed-meshheading:8415749-Genes, fos,
pubmed-meshheading:8415749-Genes, jun,
pubmed-meshheading:8415749-Genes, myc,
pubmed-meshheading:8415749-Mitosis,
pubmed-meshheading:8415749-Molecular Sequence Data,
pubmed-meshheading:8415749-Oligonucleotides, Antisense,
pubmed-meshheading:8415749-Proto-Oncogene Proteins c-myc,
pubmed-meshheading:8415749-RNA, Messenger,
pubmed-meshheading:8415749-Thymidine Kinase,
pubmed-meshheading:8415749-Tumor Necrosis Factor-alpha
|
|
pubmed:year |
1993
|
|
pubmed:articleTitle |
Tumor necrosis factor-induced c-myc expression in the absence of mitogenesis is associated with inhibition of adipocyte differentiation.
|
|
pubmed:affiliation |
Affymax Research Institute, Palo Alto, CA 94304.
|
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.
|
