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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
19
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pubmed:dateCreated |
1993-11-10
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pubmed:abstractText |
ApcMin (Min, multiple intestinal neoplasia) is a point mutation in the murine homolog of the APC gene. Min/+ mice develop multiple intestinal adenomas, as do humans carrying germ-line mutations in APC. Female mice carrying Min are also prone to develop mammary tumors. Min/+ mammary glands are more sensitive to chemical carcinogenesis than are +/+ mammary glands. Transplantation of mammary cells from Min/+ or +/+ donors into +/+ hosts demonstrates that the propensity to develop mammary tumors is intrinsic to the Min/+ mammary cells. Long-term grafts of Min/+ mammary glands also gave rise to focal alveolar hyperplasias, indicating that the presence of the Min mutation also has a role in the development of these lesions.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415640-1000487,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415640-1350108,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415640-1406932,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415640-1406933,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415640-1406937,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415640-1423316,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415640-1541640,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415640-1552940,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415640-1651174,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415640-1651562,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415640-1651563,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415640-1678319,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415640-1978757,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415640-2007094,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415640-2134734,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415640-2296722,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415640-3070862,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415640-3084509,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415640-3180072,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415640-3710160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415640-4835107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415640-6243251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415640-6802483,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8415640-7088002
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
90
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pubmed:geneSymbol |
Apc<up>Min</up>
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
8977-81
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8415640-9,10-Dimethyl-1,2-benzanthracene,
pubmed-meshheading:8415640-Adenocarcinoma,
pubmed-meshheading:8415640-Animals,
pubmed-meshheading:8415640-Crosses, Genetic,
pubmed-meshheading:8415640-Ethylnitrosourea,
pubmed-meshheading:8415640-Female,
pubmed-meshheading:8415640-Genes, APC,
pubmed-meshheading:8415640-Genetic Predisposition to Disease,
pubmed-meshheading:8415640-Hyperplasia,
pubmed-meshheading:8415640-Male,
pubmed-meshheading:8415640-Mammary Glands, Animal,
pubmed-meshheading:8415640-Mammary Neoplasms, Animal,
pubmed-meshheading:8415640-Mammary Neoplasms, Experimental,
pubmed-meshheading:8415640-Metaplasia,
pubmed-meshheading:8415640-Mice,
pubmed-meshheading:8415640-Mice, Inbred C57BL,
pubmed-meshheading:8415640-Mice, Mutant Strains,
pubmed-meshheading:8415640-Point Mutation
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pubmed:year |
1993
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pubmed:articleTitle |
ApcMin, a mutation in the murine Apc gene, predisposes to mammary carcinomas and focal alveolar hyperplasias.
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pubmed:affiliation |
McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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