|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6447
|
|
pubmed:dateCreated |
1993-11-24
|
|
pubmed:databankReference |
|
|
pubmed:abstractText |
The bone morphogenetic protein (BMP) family is a conserved group of signalling molecules within the transforming growth factor-beta (TGF-beta) superfamily. This group, including the Drosophila decapentaplegic (dpp) protein and the mammalian BMPs, mediates cellular interactions and tissue differentiation during development. Here we show that a homologue of human BMPs controls a developmental switch in the life cycle of the free-living soil nematode Caenorhabditis elegans. Starvation and overcrowding induce C. elegans to form a developmentally arrested, third-stage dauer larva. The daf-4 gene, which acts to inhibit dauer larva formation and promote growth, encodes a receptor protein kinase similar to the daf-1, activin and TGF-beta receptor serine/threonine kinases. When expressed in monkey COS cells, the daf-4 receptor binds human BMP-2 and BMP-4. The daf-4 receptor is the first to be identified for any growth factor in the BMP family.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Caenorhabditis elegans Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Transposable Elements,
http://linkedlifedata.com/resource/pubmed/chemical/Helminth Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Transforming Growth...,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
0028-0836
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
14
|
|
pubmed:volume |
365
|
|
pubmed:geneSymbol |
daf-4
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
644-9
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:8413626-Amino Acid Sequence,
pubmed-meshheading:8413626-Animals,
pubmed-meshheading:8413626-Animals, Genetically Modified,
pubmed-meshheading:8413626-Base Sequence,
pubmed-meshheading:8413626-Bone Morphogenetic Proteins,
pubmed-meshheading:8413626-Caenorhabditis elegans,
pubmed-meshheading:8413626-Caenorhabditis elegans Proteins,
pubmed-meshheading:8413626-Cell Line,
pubmed-meshheading:8413626-DNA,
pubmed-meshheading:8413626-DNA Transposable Elements,
pubmed-meshheading:8413626-Growth,
pubmed-meshheading:8413626-Haplorhini,
pubmed-meshheading:8413626-Helminth Proteins,
pubmed-meshheading:8413626-Humans,
pubmed-meshheading:8413626-Larva,
pubmed-meshheading:8413626-Molecular Sequence Data,
pubmed-meshheading:8413626-Protein Binding,
pubmed-meshheading:8413626-Protein-Serine-Threonine Kinases,
pubmed-meshheading:8413626-Proteins,
pubmed-meshheading:8413626-Receptor Protein-Tyrosine Kinases,
pubmed-meshheading:8413626-Receptors, Transforming Growth Factor beta,
pubmed-meshheading:8413626-Recombinant Proteins,
pubmed-meshheading:8413626-Sequence Homology, Amino Acid
|
|
pubmed:year |
1993
|
|
pubmed:articleTitle |
The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development.
|
|
pubmed:affiliation |
Molecular Biology Program, University of Missouri, Columbia 65211.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|
