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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6446
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pubmed:dateCreated |
1993-11-9
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pubmed:abstractText |
The 2.5 A crystal structure of a TATA-box complex with yeast TBP shows that the eight base pairs of the TATA box bind to the concave surface of TBP by bending towards the major groove with unprecedented severity. This produces a wide open, underwound, shallow minor groove which forms a primarily hydrophobic interface with the entire under-surface of the TBP saddle. The severe bend and a positive writhe radically alter the trajectory of the flanking B-form DNA.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0028-0836
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
7
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pubmed:volume |
365
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
512-20
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:8413604-Amino Acid Sequence,
pubmed-meshheading:8413604-Base Sequence,
pubmed-meshheading:8413604-Computer Graphics,
pubmed-meshheading:8413604-Crystallography, X-Ray,
pubmed-meshheading:8413604-Cytochrome c Group,
pubmed-meshheading:8413604-Cytochromes c,
pubmed-meshheading:8413604-DNA,
pubmed-meshheading:8413604-Hydrogen Bonding,
pubmed-meshheading:8413604-Molecular Sequence Data,
pubmed-meshheading:8413604-Nucleic Acid Conformation,
pubmed-meshheading:8413604-Promoter Regions, Genetic,
pubmed-meshheading:8413604-Protein Binding,
pubmed-meshheading:8413604-Protein Conformation,
pubmed-meshheading:8413604-Recombinant Proteins,
pubmed-meshheading:8413604-Saccharomyces cerevisiae,
pubmed-meshheading:8413604-Saccharomyces cerevisiae Proteins,
pubmed-meshheading:8413604-Structure-Activity Relationship,
pubmed-meshheading:8413604-TATA Box,
pubmed-meshheading:8413604-Transcription Factor TFIIA,
pubmed-meshheading:8413604-Transcription Factor TFIID,
pubmed-meshheading:8413604-Transcription Factors
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pubmed:year |
1993
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pubmed:articleTitle |
Crystal structure of a yeast TBP/TATA-box complex.
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pubmed:affiliation |
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06510.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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