Linked Life Data

8413497

Source:http://linkedlifedata.com/resource/pubmed/id/8413497

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1993-11-4
pubmed:abstractText
The effects of nine antimycotics on the biosynthesis of cellular macromolecules were analyzed using the regenerating system of protoplasts of Aspergillus niger. The incorporation of several specific radioactive precursors into major cellular components were measured in the presence or in the absence of respective agents. Miconazole, ketoconazole, and tolnaftate inhibited the lipid synthesis. 5-Fluorocytosine strongly inhibited the DNA and protein syntheses. Griseofulvin, however, specifically inhibited the synthesis of cell wall polysaccharides, i.e. chitin and glucan. Other agents showed non-specific inhibition effects. The significance of morphological change of hypha as an indicator of antimycotic action and its feasibility as a screening tool for novel antimycotic compounds are discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0301-486X
pubmed:author
pubmed:issnType
Print
pubmed:volume
122
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
135-41
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Effects of antimycotics on the biosynthesis of cellular macromolecules in Aspergillus niger protoplasts.
pubmed:affiliation
Department of Biotechnology, Faculty of Technology, Tokyo University of Agriculture and Technology, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't