| pubmed-article:8413290 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8413290 | lifeskim:mentions | umls-concept:C1442161 | lld:lifeskim |
| pubmed-article:8413290 | lifeskim:mentions | umls-concept:C0017259 | lld:lifeskim |
| pubmed-article:8413290 | lifeskim:mentions | umls-concept:C0013139 | lld:lifeskim |
| pubmed-article:8413290 | lifeskim:mentions | umls-concept:C0441587 | lld:lifeskim |
| pubmed-article:8413290 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:8413290 | pubmed:dateCreated | 1993-11-18 | lld:pubmed |
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| pubmed-article:8413290 | pubmed:abstractText | We studied the process by which whd, a P-element insertion allele of the Drosophila melanogaster white locus, is replaced by its homolog in the presence of transposase. These events are interpreted as the result of double-strand gap repair following excision of the P transposon in whd. We used a series of alleles derived from whd through P-element mobility as templates for this repair. One group of alleles, referred to collectively as whd-F, carried fragments of the P element that had lost some of the sequences needed in cis for mobility. The other group, whd-D, had lost all of the P insert and had some of the flanking DNA from white deleted. The average replacement frequencies were 43% for whd-F alleles and 7% for the whd-D alleles. Some of the former were converted at frequencies exceeding 50%. Our data suggest that the high conversion frequencies for the whd-F templates can be attributed at least in part to an elevated efficiency of repair of unexpanded gaps that is possibly caused by the closer match between whd-F sequences and the unexpanded gap endpoints. In addition, we found that the gene substitutions were almost exclusively in the direction of whd being replaced by the whd-F or whd-D allele rather than the reverse. The template alleles were usually unaltered in the process. This asymmetry implies that the conversion process is unidirectional and that the P fragments are not good substrates for P-element transposase. Our results help elucidate a highly efficient double-strand gap repair mechanism in D. melanogaster that can also be used for gene replacement procedures involving insertions and deletions. They also help explain the rapid spread of P elements in populations. | lld:pubmed |
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| pubmed-article:8413290 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8413290 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8413290 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8413290 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8413290 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:8413290 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:8413290 | pubmed:author | pubmed-author:EngelsW RWR | lld:pubmed |
| pubmed-article:8413290 | pubmed:author | pubmed-author:Johnson-Schli... | lld:pubmed |
| pubmed-article:8413290 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8413290 | pubmed:volume | 13 | lld:pubmed |
| pubmed-article:8413290 | pubmed:geneSymbol | w<up>hd-D</up> | lld:pubmed |
| pubmed-article:8413290 | pubmed:geneSymbol | w<up>hd-F</up> | lld:pubmed |
| pubmed-article:8413290 | pubmed:geneSymbol | w<up>hd</up> | lld:pubmed |
| pubmed-article:8413290 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8413290 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8413290 | pubmed:pagination | 7006-18 | lld:pubmed |
| pubmed-article:8413290 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8413290 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8413290 | pubmed:articleTitle | P-element-induced interallelic gene conversion of insertions and deletions in Drosophila melanogaster. | lld:pubmed |
| pubmed-article:8413290 | pubmed:affiliation | Genetics Department, University of Wisconsin, Madison 53706. | lld:pubmed |
| pubmed-article:8413290 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8413290 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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