Linked Life Data

8412567

Source:http://linkedlifedata.com/resource/pubmed/id/8412567

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1993-11-3
pubmed:abstractText
Carbachol produced an approximately 2-fold stimulation, with respect to basal, of [3H]inositol monophosphate ([3H]IP1) accumulation in microdissected slices of rat substantia nigra pars reticulata (SNr), measured as a percentage of [3H]inositol incorporation. The response to carbachol was inhibited by 75 +/- 7% by 1 microM pirenzepine, consistent with a muscarinic M1 receptor-mediated response. Carbachol-induced [3H]IP1 accumulation was not reduced by pretreatment of the SNr slices with NMDA, in contrast to the 85% inhibition observed in striatal slices. The results suggest that measurement of carbachol-induced phosphoinositide hydrolysis may be a feasible approach for studying muscarinic M1 receptor function in slices of SNr.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0169-328X
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
233-6
pubmed:dateRevised
2010-8-25
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Carbachol-induced phosphoinositide metabolism in slices of rat substantia nigra pars reticulata.
pubmed:affiliation
Department of Pharmacology, University of Cambridge, UK.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't