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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1993-11-1
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pubmed:abstractText |
In order to determine whether the function of alveolar macrophages (AM) is modulated by aging, we measured the TNF-alpha production, phagocytic function, and surface antigen expression of AM from young and old mice. When AM were primed by IFN-gamma (500 units/ml) and triggered by LPS (100 micrograms/ml), TNF-alpha production by AM was significantly smaller in old mice as compared with young mice (young mice: 161.7 +/- 28.2 units/ml; old mice: 89.3 +/- 13.6 units/ml, P < 0.05). The percentage of AM which phagocytosed latex particles (more than one particle) in old mice was significantly lower than in young mice (young: 78.1 +/- 2.5%; old: 62.8 +/- 3.4%, P < 0.05). Ia antigen expression of the AM was significantly higher and asialo-GM1 antigen expression was significantly lower in old mice than in young mice (Ia: young, 0.030 +/- 0.005; old, 0.092 +/- 0.024, P < 0.05; asialo-GM1: young, 0.-9 +/- 0.01; old, 0.75 +/- 0.07, P < 0.01). These results suggest that alveolar macrophage function is at least decreased in part with aging in mice.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Jul
|
pubmed:issn |
0047-6374
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
69
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pubmed:owner |
NLM
|
pubmed:authorsComplete |
N
|
pubmed:pagination |
207-17
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8412370-Aging,
pubmed-meshheading:8412370-Animals,
pubmed-meshheading:8412370-Antigens, Surface,
pubmed-meshheading:8412370-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:8412370-Cell Count,
pubmed-meshheading:8412370-Latex,
pubmed-meshheading:8412370-Macrophages, Alveolar,
pubmed-meshheading:8412370-Mice,
pubmed-meshheading:8412370-Microspheres,
pubmed-meshheading:8412370-Phagocytes,
pubmed-meshheading:8412370-Tumor Necrosis Factor-alpha
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pubmed:year |
1993
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pubmed:articleTitle |
The effects of aging on the function of alveolar macrophages in mice.
|
pubmed:affiliation |
Department of Geriatrics, Faculty of Medicine, University of Tokyo, Japan.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|