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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
21
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pubmed:dateCreated |
1993-11-19
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pubmed:abstractText |
Expression of matrix metalloproteinase-2 (MMP-2), the 72-kd type IV collagenase/gelatinase, by cancer cells has been implicated in metastasis through cancer cell invasion of basement membranes mediated by degradation of collagen IV. However, the abundance of this latent proenzyme in normal tissues and fluids suggests that MMP-2 proenzyme utilization is limited by its physiological activation rather than expression alone. We previously reported activation of this proenzyme by normal and malignant fibroblastoid cells cultured on collagen I (vitrogen) gels.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0027-8874
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
85
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1758-64
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:8411260-Breast Neoplasms,
pubmed-meshheading:8411260-Collagen,
pubmed-meshheading:8411260-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:8411260-Enzyme Activation,
pubmed-meshheading:8411260-Female,
pubmed-meshheading:8411260-Fluorescent Antibody Technique,
pubmed-meshheading:8411260-Gelatinases,
pubmed-meshheading:8411260-Humans,
pubmed-meshheading:8411260-Matrix Metalloproteinase 2,
pubmed-meshheading:8411260-Metalloendopeptidases,
pubmed-meshheading:8411260-Neoplasm Metastasis,
pubmed-meshheading:8411260-Protease Inhibitors,
pubmed-meshheading:8411260-Sensitivity and Specificity,
pubmed-meshheading:8411260-Tumor Cells, Cultured
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pubmed:year |
1993
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pubmed:articleTitle |
Association of MMP-2 activation potential with metastatic progression in human breast cancer cell lines independent of MMP-2 production.
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pubmed:affiliation |
Vincent T. Lombardi Cancer Research Center, Georgetown University Medical Center, Washington DC, 20007.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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