Linked Life Data

8411003

Source:http://linkedlifedata.com/resource/pubmed/id/8411003

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
20
pubmed:dateCreated
1993-11-9
pubmed:abstractText
Representatives of the phenylindan, -indene, and -indole classes of compounds (3-6) have been tested for affinity for the dopamine D-1 and D-2 receptors. The compounds all display high affinities for these receptors. Conformational analysis using MM2(87) and subsequent molecular least-squares superimpositions have been performed in order to determine if the affinities of the compounds can be rationalized by a recently proposed dopamine D-2 receptor-interaction model. In spite of the different geometric and conformational properties, the compounds can be well accommodated into the model in their calculated lowest energy conformations. The molecular superimpositions allow the absolute configurations of the active enantiomers of 4 and 5 to be predicted. The present structure-activity study extends the receptor-interaction model by suggesting that the receptor is not very sensitive to the orientation of the p-fluorophenyl ring in 1 and 3-6 or to the exact spatial location of the associated fluoro substituent.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0022-2623
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2878-85
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
A structure-activity study of four dopamine D-1 and D-2 receptor antagonists, representing the phenylindan, -indene, and -indole structural classes of compounds.
pubmed:affiliation
Chemical Center, University of Lund, Sweden.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't