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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1993-11-8
|
| pubmed:abstractText |
We have compared prospectively the sensitivity, specificity and accuracy of CT and MRI in a series of 27 consecutive patients (age 23-76 yrs, 17 females, 10 males) with clinically suspected primary aldosteronism. We found 13 patients with a unilateral aldosterone-producing adenoma (11 on the left and 2 on the right side), 6 with idiopathic hyper-aldosteronism and 8 with primary hypertension, which in two cases was associated with a nonfunctioning adrenal adenoma. The diagnosis of aldosterone-producing adenoma was confirmed at surgery and pathology in all cases. Idiopathic hyper-aldosteronism was diagnosed on the basis of the results of dexamethasone-suppressed adrenal scintigraphy and/or selective adrenal vein sampling. MRI correctly identified all cases of aldosterone-producing adenoma, but gave false positive results in five cases: one had idiopathic hyper-aldosteronism with bilateral nodular hyperplasia and four primary hypertension, which in two patients was associated with a nonfunctioning adrenal adenoma. Therefore, the sensitivity of MRI was 100%, its specificity 64% and overall diagnostic accuracy 81%. In comparison, CT correctly recognized only eight of the 13 patients with aldosterone-producing adenoma and gave false positive results in three primary hypertensives, including the two patients with a nonfunctioning adrenal adenoma. Therefore, its sensitivity, specificity and accuracy were 62, 77 and 69%, respectively. Based on these results, it could be anticipated that about four of every ten patients with aldosterone-producing adenoma would not be correctly diagnosed by CT.(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0950-9240
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
7
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
357-63
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8410926-Adenoma,
pubmed-meshheading:8410926-Adrenal Gland Neoplasms,
pubmed-meshheading:8410926-Adrenal Glands,
pubmed-meshheading:8410926-Adult,
pubmed-meshheading:8410926-Aged,
pubmed-meshheading:8410926-Aldosterone,
pubmed-meshheading:8410926-Dexamethasone,
pubmed-meshheading:8410926-Female,
pubmed-meshheading:8410926-Humans,
pubmed-meshheading:8410926-Hyperaldosteronism,
pubmed-meshheading:8410926-Magnetic Resonance Imaging,
pubmed-meshheading:8410926-Male,
pubmed-meshheading:8410926-Middle Aged,
pubmed-meshheading:8410926-Phlebography,
pubmed-meshheading:8410926-Prospective Studies,
pubmed-meshheading:8410926-Radionuclide Imaging,
pubmed-meshheading:8410926-Sensitivity and Specificity,
pubmed-meshheading:8410926-Tomography, X-Ray Computed,
pubmed-meshheading:8410926-Veins
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Imaging of aldosterone-secreting adenomas: a prospective comparison of computed tomography and magnetic resonance imaging in 27 patients with suspected primary aldosteronism.
|
| pubmed:affiliation |
Department of Clinical Medicine, University of Padova, Italy.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Controlled Clinical Trial
|