Linked Life Data

8408760

Source:http://linkedlifedata.com/resource/pubmed/id/8408760

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1993-11-2
pubmed:abstractText
Previous work has associated the proto-oncogene c-fos with such events as neuronal excitation and cell growth and differentiation. This study specifically examined the expression of the Fos protein as well as other Fos-related antigens (Fras) during postnatal development of rat brain. Ages P1 through P15 as well as adult animals (P60) were examined. Particular focus was placed on developing cerebral cortex, striatum, hippocampus, and cerebellum. We used both the Alu antiserum, which recognizes the Fos protein specifically, and the M5 antiserum, which recognizes both Fos and a family of Fos-related antigens. Fos and Fras were developmentally regulated in a region- and cell-specific manner. Differential nuclear and cytoplasmic labeling appeared age dependent. Transient Fos expression was generally followed by a more protracted time course of Fra expression. Fos and a delayed or an extended expression of Fras were observed in subplate neurons between P1 and P15, in striatal striosome and matrix neurons between P1 and P9, and in hippocampal pyramidal neurons between P1 and P9. Fras alone were expressed in cerebral cortex pyramidal neurons and other cortical neurons between ages P1 and P15. Fos and Fras were concomitantly expressed in piriform and entorhinal cortical neurons between P1 and P9 and in cerebellar Purkinje cells between ages P5 and P10. Constitutive levels of Fos and Fras remained detectable in adult animals in a subset of cerebral cortical neurons and cerebellar Purkinje neurons.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0021-9967
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
334
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
75-85
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Developmental regulation of Fos and Fos-related antigens in cerebral cortex, striatum, hippocampus, and cerebellum of the rat.
pubmed:affiliation
Department of Psychology, Beckman Institute, University of Illinois, Urbana-Champaign 61801.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.