| pubmed-article:8408648 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8408648 | lifeskim:mentions | umls-concept:C0042776 | lld:lifeskim |
| pubmed-article:8408648 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:8408648 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:8408648 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:8408648 | lifeskim:mentions | umls-concept:C0079784 | lld:lifeskim |
| pubmed-article:8408648 | lifeskim:mentions | umls-concept:C0018183 | lld:lifeskim |
| pubmed-article:8408648 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:8408648 | lifeskim:mentions | umls-concept:C0224522 | lld:lifeskim |
| pubmed-article:8408648 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:8408648 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
| pubmed-article:8408648 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:8408648 | pubmed:dateCreated | 1993-11-12 | lld:pubmed |
| pubmed-article:8408648 | pubmed:abstractText | The present study was performed to clarify the relationship between human T cell lymphotropic virus type I (HTLV-I) infection and chronic inflammatory arthropathy. To determine the ability of HTLV-I to infect synovial cells and the effect on synovial cell proliferation, synovial cells were cocultured with the HTLV-I-producing T cell lines (MT-2 or HCT-1). After coculture with HTLV-I-infected T cells, the synovial cells expressed HTLV-I-specific core antigens, and HTLV-I proviral DNA was detected from the synovial cells by polymerase chain reaction. These cocultured synovial cells with HTLV-I-infected T cells proliferated more actively than the synovial cells cocultured with uninfected T cells. This stimulatory effect of HTLV-I-infected T cells on synovial cell proliferation seems necessary to contact each other. After being cocultured with MT-2 cells, synovial cells proliferated more actively than control cells even after several passages. Furthermore, HTLV-I-infected synovial cells produced significant amounts of granulocyte/macrophage colony-stimulating factor. These results suggest that HTLV-I can infect synovial cells, resulting their active proliferation and may be involved in the pathogenesis of proliferative synovitis similar to that found in rheumatoid arthritis. | lld:pubmed |
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| pubmed-article:8408648 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8408648 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8408648 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:8408648 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8408648 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8408648 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:8408648 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:8408648 | pubmed:author | pubmed-author:AoyagiTT | lld:pubmed |
| pubmed-article:8408648 | pubmed:author | pubmed-author:NakamuraTT | lld:pubmed |
| pubmed-article:8408648 | pubmed:author | pubmed-author:IdaHH | lld:pubmed |
| pubmed-article:8408648 | pubmed:author | pubmed-author:KawabeYY | lld:pubmed |
| pubmed-article:8408648 | pubmed:author | pubmed-author:NakashimaMM | lld:pubmed |
| pubmed-article:8408648 | pubmed:author | pubmed-author:SakaiMM | lld:pubmed |
| pubmed-article:8408648 | pubmed:author | pubmed-author:YamashitaII | lld:pubmed |
| pubmed-article:8408648 | pubmed:author | pubmed-author:EguchiKK | lld:pubmed |
| pubmed-article:8408648 | pubmed:author | pubmed-author:TeradaKK | lld:pubmed |
| pubmed-article:8408648 | pubmed:author | pubmed-author:TakinoHH | lld:pubmed |
| pubmed-article:8408648 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8408648 | pubmed:volume | 92 | lld:pubmed |
| pubmed-article:8408648 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8408648 | pubmed:authorsComplete | N | lld:pubmed |
| pubmed-article:8408648 | pubmed:pagination | 1957-66 | lld:pubmed |
| pubmed-article:8408648 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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