Linked Life Data

8407546

Source:http://linkedlifedata.com/resource/pubmed/id/8407546

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1993-11-17
pubmed:abstractText
The thymoma-prone rat of the BUF/Mna strain is a useful model for human thymoma. In this strain thymoma development is regulated by a single autosomal susceptible gene, Tsr-1. At pre-thymoma age, BUF/Mna rats have extremely large thymuses, when compared to those of other strains of rats. Genetic studies in crosses between BUF/Mna rats with large thymuses and WKY/NCrj rats with small thymuses suggested the presence of a major autosomal gene, Ten-1, which contributes to thymus enlargement in a backcross population. Linkage studies between Ten-1 and microsatellite markers in backcross rats of (WKY/NCrj x BUF/Mna)F1 x BUF/Mna have led to the localization of Ten-1 in chromosome 1. This result may provide an approach to clone Tsr-1, which could be allelic to Ten-1.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0910-5050
pubmed:author
pubmed:issnType
Print
pubmed:volume
84
pubmed:geneSymbol
Ten-1, Tsr-1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
838-40
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Chromosomal mapping of genetic locus associated with thymus-size enlargement in BUF/Mna rats.
pubmed:affiliation
Department of Pathology, Nagoya University School of Medicine.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't